Vol. 18 No. 1 (2014)
NEW RESEARCH RESULTS AND TECHNOLOGIES

Functional characteristics of peripheral blood mononuclear cells after administration of granulocyte colony-stimulating factor in patients with chronic heart failure

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  • O. Poveshchenko,
  • I. Kim,
  • N. Bondarenko,
  • A. Lykov,
  • A. Poveshchenko,
  • Ye. Pokushalov,
  • A. Romanov,
  • A. Karaskov,
  • V. Konenkov
O. Poveshchenko
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
I. Kim
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
N. Bondarenko
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Lykov
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Poveshchenko
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
Ye. Pokushalov
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Romanov
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Karaskov
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
V. Konenkov
Research Institute of Clinical and Experimental Lymрhology SB RAMS; Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
DOI: https://doi.org/10.21688/1681-3472-2014-1-26-31

Published 2014-02-28

Keywords

  • GRANULOCYTE COLONY-STIMULATING FACTOR,
  • CYTOKINES,
  • PROGENITOR CELLS,
  • CORONARY HEART DISEASE

How to Cite

Poveshchenko, O., Kim, I., Bondarenko, N., Lykov, A., Poveshchenko, A., Pokushalov, Y., Romanov, A., Karaskov, A., & Konenkov, V. (2014). Functional characteristics of peripheral blood mononuclear cells after administration of granulocyte colony-stimulating factor in patients with chronic heart failure. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 18(1), 26–31. https://doi.org/10.21688/1681-3472-2014-1-26-31

Copyright (c) 2014 Poveshchenko O.V., Kim I.I., Bondarenko N.A., Lykov A.P., Poveshchenko A.F., Pokushalov Ye.A., Romanov A.B., Karaskov A.M., Konenkov V.I.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

It is shown that the introduction of granulocyte colony stimulating factor (G-CSF) in patients with chronic heart failure increases the functional activity of peripheral blood mononuclear cells (MNC). Enriching peripheral blood MNCs with progenitor cells (PC) by mobilization of bone marrow leads to an increase of their proliferative capacity both under spontaneous culture conditions and when stimulated with ConA mitogen and cytokines G-CSF. Proliferative activity of MNCs is found to increase, as the number of CD34+ PC starts growing. It is also noted that MNCs produce a wide range of cytokines with regulatory action after mobilization in a 48-hour culture in vitro. The findings suggest the feasibility of using MNCs after G-CSF mobilization for stimulation of reparative processes in the myocardium.

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