Vol. 16 No. 2 (2012)
MORPHOLOGY AND PATHOMORPHOLOGY

Morpho-functional evaluation of enzymatic and detergent decellularization methods of cardiac allografts

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  • M. Vasileva,
  • D. Sergeevichev,
  • A. Yunoshev,
  • P. Larionov,
  • R. Novruzov,
  • A. Karaskov
M. Vasileva
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
D. Sergeevichev
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Yunoshev
Lavrentiev Institute of Hydrodynamics SB RAS
Bio
P. Larionov
Novosibirsk Research Institute of Traumatology and Orthopedics
Bio
R. Novruzov
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
A. Karaskov
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
DOI: https://doi.org/10.21688/1681-3472-2012-2-77-80

Published 2012-07-03

Keywords

  • BIOLOGICAL HEART VALVE,
  • ALLOGRAFT,
  • DECELLULARIZATION,
  • STRAIN GAUGES

How to Cite

Vasileva, M., Sergeevichev, D., Yunoshev, A., Larionov, P., Novruzov, R., & Karaskov, A. (2012). Morpho-functional evaluation of enzymatic and detergent decellularization methods of cardiac allografts. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 16(2), 77–80. https://doi.org/10.21688/1681-3472-2012-2-77-80

Copyright (c) 2012 Vasileva M.B., Sergeevichev D.S., Yunoshev A.S., Larionov P.M., Novruzov R.B., Karaskov A.M.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

In this study we conducted a comparative analysis of enzyme and detergent methods of decellurizing cardiac allografts. It was shown that by using the detergent method, the highest degree of purification of the valve from the cells could be achieved, while preserving its original mechanical strength and the spatial structure of its matrix. Based on these data, the detergent method can be recommended as a preferred choice during preparation of allografts for use in cardiac surgery practice.
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