Vol. 20 No. 3 (2016)
VASCULAR SURGERY

Comparative evaluation of dermal equivalent effectiveness in neuropathic/and neuroischemic form of diabetic foot syndrome

PDF (Русский)
  • A Kotslova,
  • M Binienko,
  • A Galileeva,
  • N Yudintseva,
  • S Sheyanov,
  • V Davidenko,
  • T Vlasov
A Kotslova
Pavlov First Saint Petersburg State Medical University, Ministry of Health Care of Russian Federation, 197022 Saint Petersburg, Russian Federation; City Hospital No. 14, 198099 Saint Petersburg, Russian Federation
Bio
M Binienko
Pavlov First Saint Petersburg State Medical University, Ministry of Health Care of Russian Federation, 197022 Saint Petersburg, Russian Federation; City Hospital No. 14, 198099 Saint Petersburg, Russian Federation; Hospital for veterans of wars, 193079 Saint Petersburg, Russian Federation
Bio
A Galileeva
Pavlov First Saint Petersburg State Medical University, Ministry of Health Care of Russian Federation, 197022 Saint Petersburg, Russian Federation
Bio
N Yudintseva
Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russian Federation
Bio
S Sheyanov
City Hospital No. 14, 198099 Saint Petersburg, Russian Federation
Bio
V Davidenko
Pavlov First Saint Petersburg State Medical University, Ministry of Health Care of Russian Federation, 197022 Saint Petersburg, Russian Federation
Bio
T Vlasov
Pavlov First Saint Petersburg State Medical University, Ministry of Health Care of Russian Federation, 197022 Saint Petersburg, Russian Federation
Bio
DOI: https://doi.org/10.21688/1681-3472-2016-3-62-71

Published 2016-11-10

Keywords

  • diabetic foot syndrome,
  • diabetic ulcer,
  • diabetes mellitus type 2,
  • microangiopathy,
  • macroangiopathy,
  • dermal equivalent,
  • granulation,
  • epithelialization
    • ...More
    Less

How to Cite

Kotslova, A., Binienko, M., Galileeva, A., Yudintseva, N., Sheyanov, S., Davidenko, V., & Vlasov, T. (2016). Comparative evaluation of dermal equivalent effectiveness in neuropathic/and neuroischemic form of diabetic foot syndrome. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 20(3), 62–71. https://doi.org/10.21688/1681-3472-2016-3-62-71

Copyright (c) 2016 Kotslova A.A., Binienko M.A., Galileeva A.N., Yudintseva N.M., Sheyanov S.D., Davidenko V.V., Vlasov T.D.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. It was to evaluate the effectiveness of dermal equivalent application when treating ulcers in patients with neuropathic and neuroischemic forms of diabetic foot syndrome (DFS), as well as to compare it with conventional treatment.
Methods. The study included 60 patients with DFS neuropathic and neuroischemic forms who were treated at Purulent Surgery Departments of War Veterans Hospital and City Hospital No. 14 (Saint Petersburg, Russia) in 2013–2016 years. The patients were divided in two subgroups comparable in age and sex: subgroup A included patients with DFS neuropatic form, subgroup B – those with DFS neuroischemic form. Thus, the study group of patients was formed, who, in addition to conventional treatment of diabetic ulcers, received dermal equivalent application. To assess the effectiveness of dermal equivalent use, two control groups: 10 patients with a neuropathic form and 10 patients with a neuroischemic form of DFS were formed and routinely managed.
Results. 33 patients (82.5%) (18 patients from subgroup A and 15 patients from subgroup B) out of 40 patients of the study group demonstrated a significantly higher rate of epithelization (p<0.05) as compared to the corresponding subgroup in the control group.
Conclusion. The efficacy of dermal equivalent is higher when treating a neuropathic form of DFS. The speed of epithelization after the use of dermal equivalent in patients with a neuropathic form of DFS is higher in comparison with a neuroischemic form of DFS.

Received 5 August 2016. Accepted 23 September 2016.

Funding: The study has not been sponsored or awarded a grant.
Conflict of interest: The authors declare no conflict interests.

PDF (Русский)

References

  1. Ignatovich IN, Kondratenko GG. Khirurgiya i angiologiya diabeticheskoy stopy. Minsk: Publ. Taktik-Studio; 2013. 304 p. (In Russ.).
  2. Pavlova MG, Gusov TV, Lavrishcheva NV. Trudnyy patsient. 2006;4(1):32-8. (In Russ.)
  3. Apelqvist J, Bakker K, van Houtum WH, Nabuurs-Franssen MH, Schaper NC. International consensus and practical guidelines on the management and the prevention of the diabetic foot. International Working Group on the Diabetic Foot. Diabetes Metab Res Rev. 2000;16(Suppl 1):S84-92.
  4. Kotslova AA, Davidenko VV, Vlasov TD. Local changes in microcirculation in patients with neuroischemic and neuropathic forms of the diabetic foot syndrome. Laser Medicine. 2016;20(2):5-12. (In Russ.).
  5. Lev-Tov H, Li CS, Dahle S, Isseroff RR. Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial. Trials. 2013;14:8. DOI: 10.1186/1745-6215-14-8.
  6. Larsson J, Agardh CD, Apelquist J, Stenstorm A. Long-term prognosis after healed amputation in patients with diabetes. Clin Orthop Relat Res. 1998;350:149-58.
  7. Vinnik YuS, Salmina AB, Drobushevskaya AI, Teplyakova OV, Pozhilenkova EA, Zykova LD. The cell technologies and the tissue engineering are for healing chronic wounds. Vestnik of Experimental and Clinical Surgery = Journal of Experimental and Clinical Surgery. 2011;4(2):392-7. (In Russ.).
  8. Gostishchev VK, Lipatov KV, Komarova EA, Kho BO, Marakutsa EV. Plastic surgery in patients with soft-tissue infection. Khirurgiya. Zhurnal imeni N.I. Pirogova = Journal Surgery named after N.I. Pirogov. 2009;12:19-24. (In Russ.).
  9. Yarets YuI, Novikova IA. Laboratory prognosis of a risk of rejection of autodermotransplant. Vestnik khirurgii. 2010;169(2):34-8. (In Russ.).
  10. Zorin VL, Zorina AI, Petrakova OS, Cherkasov VR. Genes & Cells. 2009;4(4):26-40. (In Russ.).
  11. Bushberger B, Follmann M, Freyer D, Huppertz H, Ehm A, Wasem J. The importance of growth factors for the treatment of chronic wounds in the case of diabetic foot ulcers. GMS Health Technol Assess. 2010;6:Doc12. DOI: 10.3205/hta000090.
  12. Hart CE, Loewen-Rodriguez A, Lessem J. Dermagraft: Use in the Treatment of Chronic Wounds. Advances in wound care. 2012;1(3):138-141. DOI: 10.1089/wound.2011.0282.
  13. Jadlowiec C, Brenes RA, Li X, Lv W, Protack CD, Collins MJ, Dardik A. Stem cell therapy for critical limb ischemia: What can we learn from cell therapy for chronic wounds? Vascular. 2011;20(5):284-289. DOI: 10.1258/vasc.2011.201206.
  14. Langer A, Rogowski W. Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers. BMC Health Serv Resc. 2009;9:115. DOI: 10.1186/1472-6963-9-115.
  15. Meltsova AZh, Grotsenko VV, Orlovsky PI, Tomson VV, Sabelnikov VV, Shulepova EK, Prokopets AI, Pinaev GP, Blinova MI, Yudintseva NM. Application of dermal fibroblasts in complex treatment of patients with trophic ulcers of venous etiology. Vestnik khirurgii imeni I.I. Grekova. 2007;166(1):72-7. (In Russ.).
  16. Sedov VM, Andreev DYu, Smirnova TD, Paramonov BA, Enkina TN, Sominina AA, Kiselev OI, Suissi YuYu, Lebedev LV. The efficacy of cell therapy in the treatment of patients with trophic venous ulcers of the lower limbs. Angiologiya i sosudistaya khirurgiya = Angiology and Vascular Surgery. 2007;13:65-75. (In Russ.)
  17. Lapin AYu, Skryabin ON, Rubtsov MA. Statsionarozameshchayushchie tekhnologii: ambulatornaya khirurgiya. 2014;1-2:5-11. (In Russ.).
  18. Blinova IM, Udintsev NM, Aleksandrova OI, Ballyuzek MF, Khabarova IG, Markin SM, Chagunava OL. Clinical experience healing of venous ulcers with the use of a cellular product "The dermal equivalent ED". Zdorove - osnova chelovecheskogo potentsiala: problemy i puti ikh resheniya. 2015;10(2):690-4. (In Russ.).