Vol. 20 No. 3 (2016)
REVIEWS

Myeloid suppressor cells in the pathogenesis of critical states

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  • E Grigoryev,
  • D Shukevich,
  • V Matveeva,
  • S Pugachev,
  • E Kameneva,
  • R Kornelyuk
E Grigoryev
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russian Federation; Kemerovo State Medical University, Ministry of Health Care of Russian Federation, 650029 Kemerovo, Russian Federation
Bio
D Shukevich
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russian Federation; Kemerovo State Medical University, Ministry of Health Care of Russian Federation, 650029 Kemerovo, Russian Federation
Bio
V Matveeva
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russian Federation
Bio
S Pugachev
City Clinical Hospital No. 3, 650000 Kemerovo, Russian Federation
Bio
E Kameneva
Kemerovo State Medical University, Ministry of Health Care of Russian Federation, 650029 Kemerovo, Russian Federation; City Clinical Hospital No. 3, 650000 Kemerovo, Russian Federation
Bio
R Kornelyuk
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russian Federation
Bio
DOI: https://doi.org/10.21688/1681-3472-2016-3-20-25

Published 2016-11-10

Keywords

  • systemic inflammatory response,
  • critical states,
  • myeloid suppressor cells

How to Cite

Grigoryev, E., Shukevich, D., Matveeva, V., Pugachev, S., Kameneva, E., & Kornelyuk, R. (2016). Myeloid suppressor cells in the pathogenesis of critical states. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 20(3), 20–25. https://doi.org/10.21688/1681-3472-2016-3-20-25

Copyright (c) 2016 Grigoryev E.V., Shukevich D.L., Matveeva V.G., Pugachev S.V., Kameneva E.A., Kornelyuk R.A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Critical states, regardless of the cause, are characterized by the formation of a systemic inflammatory response with multi-directional translations of pro- and anti-inflammatory mediators. Under the conditions of uncontrolled inflammation and the development of persistent organ failure, there exists a possibility of developing uncontrolled abnormal myelopoesis that might result in a release of myeloid suppressor cells. The purpose of the overview is to determine the role of myeloid suppressor cells in the development of immune suppression in critical states from the viewpoint of diagnostic significance, with the focus on both sterile and infectious systemic inflammation.

Received 20 April 2016. Accepted 18 August 2016.

Funding: The study had no sponsorship.
Conflict of interest: The authors declare no conflict of interest.

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