Vol. 18 No. 4 (2014): Heart Rhythm Disoders (Special Issue)
HEART FAILURE

Cardiac contractility modulation in treatment of patients with chronic heart failure

Yu. Mareev
A.L. Myasnikov Institute of Clinical Cardiology
Bio

Published 2014-10-28

Keywords

  • CHRONIC HEART FAILURE,
  • CARDIAC CONTRACTILITY MODULATION

How to Cite

Mareev, Y. (2014). Cardiac contractility modulation in treatment of patients with chronic heart failure. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 18(4), 158–163. https://doi.org/10.21688/1681-3472-2014-4-158-163

Abstract

Chronic heart failure is a condition with high mortality and morbidity. Cardiac contractility modulation (CCM) is a modern method for treating patients with CHF. There is evidence that CCM improves quality of life and exercise tolerance of patients. There is no sufficient data that MCC can improve a patients prognosis. We need more data to understand the place of MCC in treatment of patients with CHF.

References

  1. Фомин И.В., Беленков Ю.Н., Мареев В. Ю. и др. Распространенность хронической сердечной недостаточности в европейской части Российской Федерации. Данные ЭПОХА-ХСН. Ж. Сердечная недостаточность, 2006; 37: 112-5.
  2. Беленков Ю.Н., Мареев В.Ю. Лечение сердечной недостаточности в 21 веке: достижение, вопросы и уроки доказательной медицины. Кардиология 2008; 2: 6-16.
  3. Moss A.J., Zareba W., Hall W.J. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N. Engl. J. Med. 2002; 346 (12): 877-83.
  4. Bardy G.H., Lee K.L., Mark D.B., et al. Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N. Engl. J. Med. 2005; 352 (3): 225-37.
  5. Cleland J.G., Daubert J.C., Erdmann E., et al. Longer-term effects of cardiac resynchronization therapy on mortality in heart failure . Eur. Heart J. 2006; 27 (16): 1928-32.
  6. Brenyo A., Rao M., Barsheshet A., et al. QRS axis and the benefit of cardiac resynchronization therapy in patients with mildly symptomatic heart failure enrolled in MADIT-CRT. J. Cardiovasc. Electrophysiol. 2013; 24 (4): 442-8.
  7. Ruschitzka F., Abraham W.T., Singh J.P., et al. Cardiacresynchronization therapy in heart failure with a narrow QRS complex. N. Engl. J. Med. 2013; 369 (15): 1395-405.
  8. Stavrakis S., Lazzara R., Thadani U. The Benefit of Cardiac Resynchronization Therapy and QRS Duration: A Meta-Analysis. Journal of Cardiovascular Electrophysiology. 2012; 23 (2): 163-68.
  9. Zareba W., Klein H., Cygankiewicz I. Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation. 2011; 123 (10): 1061-72.
  10. Imai M., Rastogi S., Gupta R.C., Mishra S., Sharov V.G., et al. Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J. Am. Coll. Cardiol. 2007; 49: 2120-28.
  11. Winter J., Brack K.E., Ng G.A. Cardiac contractility modulation in the treatment of heart failure: initial results and unanswered questions. Eur. J. Heart Fail. 2011; 13: 700-10.
  12. Butter C., Wellnhofer E., Schlegl M., Winbeck G., Fleck E., Sabbah H.N. Enhanced inotropic state of the failing left ventricle by cardiac contractility modulation electrical signals is not associated with increased myocardial oxygen consumption. J. Card. Fail. 2007; 13: 137-42.
  13. Nelson G.S., Berger R.D., Fetics B.J., et al. Left Ventricular or Biventricular Pacing Improves Cardiac Function at Diminished Energy Cost in Patients With Dilated Cardiomyopathy and Left Bundle-Branch Block. Circulation 2000; 102: 3053-59.
  14. Pappone C., Vicedomini G., Salvati A., et al. Electrical modulation of cardiac contractility: clinical aspects in congestive heart failure. Heart Fail. Rev. 2001; 6: 55-60.
  15. Pappone C., Rosanio S., Burkhoff D., et al. Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am. J. Cardiol. 2002; 90: 1307-13.
  16. Borggrefe M.M., Lawo T., Butter C., et al. Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure. Eur. Heart J. 2008; 29 (8): 1019-28.
  17. Yu C.M., Chan J.Y., Zhang Q., et al. Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling. JACC Cardiovasc. Imaging. 2009; 2 (12): 1341-9.
  18. Kadish A., Nademanee K., Volosin K., et al. A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. Am. Heart J. 2011; 161 (2): 329-37.e1-2.
  19. Giallauria F., Vigorito C., Piepoli M., et al. Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: An individual patients data meta-analysis of randomized controlled trials. Int. J. Cardiol. 2014; 175 (2): 352-7.
  20. Kwong J.S., Sanderson J.E., Yu C.M. Cardiac contractility modulation for heart failure: a meta-analysis of randomized controlled trials. Pacing Clin. Electrophysiol. 2012; 35 (9): 1111-8.
  21. Kloppe. Long-Term Survival with CCM in Patients with NYHA II or III and Normal QRS Duration. HFA 2014. Late braking clinical trials III.