Vol. 29 No. 4 (2025): Patologiya krovoobrashcheniya i kardiokhirurgiya
EXPERIMENTAL STUDIES

Local chemical ablation of myocardium via transvenous access: results of an experimental study

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  • David S. Sergeevichev,
  • Aryuna Yu. Tsydenova,
  • Ivan S. Murashov,
  • Vladislav V. Fomenko,
  • Elena V. Kuznetsova,
  • Vladimir M. Nazarov,
  • Alexander B. Romanov
David S. Sergeevichev
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Aryuna Yu. Tsydenova
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Ivan S. Murashov
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Vladislav V. Fomenko
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Elena V. Kuznetsova
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Vladimir M. Nazarov
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Alexander B. Romanov
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
DOI: https://doi.org/10.21688/1681-3472-2025-4-25-32

Published 2026-01-21

Keywords

  • chemical ablation; coronary veins; experimental cardiology; multiballoon technique; ventricular tachycardia; VVF34

How to Cite

Sergeevichev, D. S. S., Tsydenova, A. Y. T., Murashov, I. S. M., Fomenko, V. V. F., Kuznetsova, E. V. K., Nazarov, V. M. N., & Romanov, A. B. R. (2026). Local chemical ablation of myocardium via transvenous access: results of an experimental study. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 29(4), 25–32. https://doi.org/10.21688/1681-3472-2025-4-25-32

Copyright (c) 2026 Давид Сергеевич Сергеевичев, Арюна Юрьевна Цыденова, Иван Сергеевич Мурашов, Владислав Викторович Фоменко, Елена Владимировна Кузнецова, Владимир Михайлович Назаров, Александр Борисович Романов

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Ventricular tachycardia, especially in patients with structural heart disease, is a life-threatening condition. Standard methods, such as radiofrequency ablation, are often ineffective against deep or epicardial arrhythmogenic foci, and transarterial chemical ablation with ethanol is insufficiently selective and risk- bearing for extensive myocardial damage. A retrograde transvenous approach for myocardial chemical ablation, exploiting the high permeability of coronary vein walls, is being considered as an alternative.

Objective: The study was aimed to assess the efficacy and safety on formation of local myocardial chemical ablation using selective injection of an aliphatic VVF34 composition into an isolated coronary vein segment.

Methods: The study was performed on minipigs (n = 4). The target segment of the coronary vein was isolated using a multi-balloon occlusion technique, followed by the injection of 1 ml of the VVF34 composition. Histological examinations of the myocardium were performed at 1 and 3 months after intervention to assess fibrosis formation.

Results: The procedure was successfully completed in all animals without intra- or postoperative complications. Histological analysis confirmed the formation of sharply marginated fibrosis foci in the myocardium adjacent to the injection site. The active inflammatory reaction and initial fibrotic degeneration were revealed at 1 month after injection, and the formation of mature homogeneous areas of sclerosis without significant inflammatory infiltration was identified 3 months later.

Conclusion: The transvenous chemical myocardial ablation with VVF34 composition using balloon isolation of venous segment has proven its efficacy and safety in the experiment. This approach enables to create controlled zones of fibrosis and is promising for highly selective targeting of deep and epicardial arrhythmogenic origins inaccessible to radiofrequency ablation, opening new possibilities for the treatment of resistant arrhythmias

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