Vol. 17 No. 2 (2013)
ANESTHESIOLOGY & RESUSCITATION

Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients

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  • I. Ponomarenko,
  • V. Shipulin,
  • O. Ogurkova,
  • T. Suslova
I. Ponomarenko
Research Institute for Cardiology
Bio
V. Shipulin
Research Institute for Cardiology
Bio
O. Ogurkova
Research Institute for Cardiology
Bio
T. Suslova
Research Institute for Cardiology
Bio
DOI: https://doi.org/10.21688/1681-3472-2013-2-51-56

Published 2013-05-15

Keywords

  • CARDIOPULMONARY BYPASS,
  • BIOCOMPATIBLE COATINGS,
  • INFLAMMATORY RESPONSE,
  • RESPIRATORY INDICES

How to Cite

Ponomarenko, I., Shipulin, V., Ogurkova, O., & Suslova, T. (2013). Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 17(2), 51–56. https://doi.org/10.21688/1681-3472-2013-2-51-56

Copyright (c) 2013 Ponomarenko I.V., Shipulin V.M., Ogurkova O.N., Suslova T.Ye.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Biocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated circuit (control, n=18). Leukocyte and platelet counts, levels of tumor necrosis factor, interleukin-6 and fibrinogen were assessed in arterial blood before, during and after cardiopulmonary bypass (CPB). Oxygenation and ventilation indices before and after surgery, post-operative chest tube drainage and transfusion volume as well as the duration of assisted ventilation were also measured. A platelet count and fibrinogen dropped less in the Bioline group significantly compared with that in control at the end of CPB (p<0,05) and after protamine administration (p<0,05). A leukocyte count and an interleukin-6 level increased more in controls after CPB (p<0,05) as well as oxygenation and ventilation indices, bleeding volume and intubation time (all p<0,05). Our results suggest surface heparinization with Bioline coating limited to the oxygenator ameliorates the inflammatory response, preserves fibrinogen and platelets, reduces blood loss postoperatively and improves lung function during CPB.
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