Vol. 27 No. 1 (2023)
ACQUIRED HEART DISEASES

Aortic allografts for surgical treatment of prosthetic valve endocarditis

PDF (Русский)
  • A.V. Bogachev-Prokophiev,
  • R.M. Sharifulin,
  • S.I. Zheleznev,
  • A.V. Karadzha,
  • A.V. Afanasyev,
  • A.N. Pivkin,
  • A.S. Zalesov
A.V. Bogachev-Prokophiev
Meshalkin National Medical Research Center
R.M. Sharifulin
Meshalkin National Medical Research Center
Bio
S.I. Zheleznev
Meshalkin National Medical Research Center
A.V. Karadzha
Meshalkin National Medical Research Center
A.V. Afanasyev
Meshalkin National Medical Research Center
A.N. Pivkin
Meshalkin National Medical Research Center
A.S. Zalesov
Meshalkin National Medical Research Center
The survival rate (Kaplan–Meier curve)
DOI: https://doi.org/10.21688/1681-3472-2023-1-7-16

Published 2023-03-30

Keywords

  • Allografts,
  • Endocarditis,
  • Heart Valve Prosthesis,
  • Retrospective Studies,
  • Staphylococcus aureus

How to Cite

Bogachev-Prokophiev, A., Sharifulin, R., Zheleznev, S., Karadzha, A., Afanasyev, A., Pivkin, A., & Zalesov, A. (2023). Aortic allografts for surgical treatment of prosthetic valve endocarditis. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 27(1), 7–16. https://doi.org/10.21688/1681-3472-2023-1-7-16

Copyright (c) 2023 Bogachev-Prokophiev A.V., Sharifulin R.M., Zheleznev S.I., Karadzha A.V., Afanasyev A.V., Pivkin A.N., Zalesov A.S.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Prosthetic valve endocarditis, the most severe form of infective endocarditis, occurs in 1-6% of patients with valve prostheses and is still associated with poor prognosis and high in-hospital mortality.
Objective: To assess outcomes of allograft aortic root replacement in patients with prosthetic valve endocarditis.
Methods: The retrospective analysis included adult patients with prosthetic valve endocarditis, who underwent allograft aortic root replacement between 2011 and 2022.
Results: Of 15 study patients, early infective endocarditis was found in 60.0% of the cases. The most common cause was Staphylococcus aureus (26.7%). Early mortality was 13.3%. Thromboembolic events occurred in 2 patients (13.3%). The median follow-up period was 48.5 (6-140) months. Late death was reported in 1 patient. The 5-year survival rate was 79.0%. One patient had recurrent infective endocarditis. Two patients underwent reintervention: one for a proximal anastomotic pseudoaneurysm and another one for structural degeneration of the allograft. Five-year freedom from reintervention was 91.7%.
Conclusion: Due to the high rate of the freedom from recurrent infective endocarditis, allograft aortic root replacement is an effective treatment for patients with prosthetic valve endocarditis.

Received 7 November 2022. Revised 9 December 2022. Accepted 20 December 2022.

Funding: The study was supported by the grant of the president of the Russian Federation (No. 075-15-2022-823).

Conflict of interest: The authors declare no conflict of interest.

Contribution of the authors
Conception and study design: A.V. Bogachev-Prokophiev
Data collection and analysis: A.V. Karadzha, A.N. Pivkin, A.S. Zalesov
Statistical analysis: R.M. Sharifulin, A.V. Afanasyev
Drafting the article: R.M. Sharifulin, A.V. Afanasyev
Critical revision of the article: A.V. Bogachev-Prokophiev, S.I. Zheleznev
Final approval of the version to be published: A.V. Bogachev-Prokophiev, R.M. Sharifulin, S.I. Zheleznev, A.V. Karadzha, A.V. Afanasyev, A.N. Pivkin, A.S. Zalesov

PDF (Русский)

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