Vol. 26 No. 3 (2022)
REVIEWS

Valve-sparing aortic root replacement in patients with Marfan syndrome: a systematic review

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  • R.N. Komarov,
  • A.U. Normuradov,
  • R.M. Isaev,
  • M.A. Soborov,
  • A.I. Ropova,
  • V.D. Reiter
R.N. Komarov
Sechenov University
A.U. Normuradov
Sechenov University
Bio
R.M. Isaev
Sechenov University
M.A. Soborov
Sechenov University
A.I. Ropova
Sechenov University
V.D. Reiter
Sechenov University
DOI: https://doi.org/10.21688/1681-3472-2022-3-21-30

Published 2022-09-30

Keywords

  • Aneurysm, Dissecting,
  • Aortic Aneurysm, Thoracic,
  • Aortic Valve,
  • Aortic Valve Insufficiency,
  • Blood Vessel Prosthesis Implantation,
  • Marfan Syndrome,
  • Replantation
    • ...More
    Less

How to Cite

Komarov, R., Normuradov, A., Isaev, R., Soborov, M., Ropova, A., & Reiter, V. (2022). Valve-sparing aortic root replacement in patients with Marfan syndrome: a systematic review. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 26(3), 21–30. https://doi.org/10.21688/1681-3472-2022-3-21-30

Copyright (c) 2022 Komarov R.N., Normuradov A.U., Isaev R.M., Soborov M.A., Ropova A.I., Reiter V.D.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. To analyze the literature about the results of valve-sparing operations in aortic root surgery in patients with Marfan syndrome.
Methods. A comprehensive search included four databases: Pubmed, Embase, Cochrane Library, and Web of Science. Articles for analysis were selected according to the methods presented in the PRISMA 2020 guidelines.
Results. The final systematic review included 19 studies and 4 meta-analyses. The findings showed that 30-day and hospital mortality rates did not exceed 2.08%. The incidence of thromboembolism over a 15-year period was 4.1 ± 2.0%. The mean rate of infective endocarditis was 0.25%. Freedom from severe aortic insufficiency 8 years after surgery was 95.2 ± 3.3%. Freedom from reoperation at 8 and 10 years was 97%. Long-term mortality was ≤ 10.57%. The 5-, 10-year survival rates were 95.4 and 84.2% respectively.
Conclusion. Valve-sparing operations are more beneficial than valved conduits in patients with Marfan syndrome in the short and long-term periods. Thromboembolism, endocarditis, and bleeding were significantly more common in patients with valved conduits in the long-term period.

Received 7 February 2022. Revised 16 May 2022. Accepted 18 May 2022.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.

Contribution of the authors
Conception and study design: A.U. Normuradov, R.M. lsaev, M.A. Soborov, A.I. Ropova, V.D. Reiter
Drafting the article: A.U. Normuradov, R.M. lsaev, A.I. Ropova, V.D. Reiter
Critical revision of the article: A.U. Normuradov, R.M. lsaev
Final approval of the version to be published: R.N. Komarov, A.U. Normuradov, R.M. Isaev, M.A. Soborov, A.I. Ropova, V.D. Reiter

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