Vol. 24 No. 2 (2020)
ACQUIRED HEART DISEASES

Early results of surgery for aortic valve disease in patients with severe left ventricular dysfunction

S. Babeshko
Research Institute – S. V. Ochapovsky Regional Clinic Hospital No. 1, Ministry of Health of Krasnodar Region, Krasnodar
Bio
Yu. Samurganov
Kuban State Medical University, Ministry of Health of Russian Federation, Krasnodar
D. Shumkov
Research Institute – S. V. Ochapovsky Regional Clinic Hospital No. 1, Ministry of Health of Krasnodar Region, Krasnodar
K. Barbukhatti
Research Institute – S. V. Ochapovsky Regional Clinic Hospital No. 1, Ministry of Health of Krasnodar Region, Krasnodar; Kuban State Medical University, Ministry of Health of Russian Federation, Krasnodar
V. Porkhanov
Research Institute – S. V. Ochapovsky Regional Clinic Hospital No. 1, Ministry of Health of Krasnodar Region, Krasnodar; Kuban State Medical University, Ministry of Health of Russian Federation, Krasnodar

Published 2020-07-03

Keywords

  • aortic valve disease,
  • aortic valve replacement,
  • cardiac surgery,
  • severe left ventricular dysfunction

How to Cite

Babeshko, S., Samurganov, Y., Shumkov, D., Barbukhatti, K., & Porkhanov, V. (2020). Early results of surgery for aortic valve disease in patients with severe left ventricular dysfunction. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 24(2), 63–72. https://doi.org/10.21688/1681-3472-2020-2-63-72

Abstract

Aim. This study aimed to analyse the early results of aortic valve replacement in patients with severe left ventricular dysfunction: i.e. a left ventricle ejection fraction (LVEF) ≤30%.
Methods. This retrospective study included 145 adult patients with isolated aortic valve disease and LVEF ≤30% who underwent aortic valve replacement from 2005 to 2019 at our institution. Patients who required any concomitant or redo surgery were excluded from the study.
Results. There were three perioperative deaths (in-hospital mortality, 2.1%) due to multiple organ failure syndrome (two patients) or acute heart failure (one patient). Postoperative heart failure was the prevailing non-lethal complication (73% of cases). Other complications occurred less frequently: nine patients (6.2%) had acute kidney injury (four of whom required hemodiafiltration), one patient (0.7%) suffered a stroke, six patients (4%) required chest re-exploration for bleeding and two patients (1.4%) experienced sternal infection of the surgical wound. Patient LVEF improved significantly from 22.6% ± 5.3% to 35.8% ± 11.0% postoperatively (a 37% mean increase; p = 0.02), and most patients (73%) were classified as New York Heart Association class I–II by the time of discharge.
Conclusion. Our study showed excellent results of surgery for aortic valve disease in patients with severe left ventricular dysfunction. Postoperatively, there was a marked increase in LVEF and significant clinical improvement.

Received 1 May 2020. Revised 12 May 2020. Accepted 18 May 2020.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.

Author contributions
Conception and design: S.S. Babeshko, K.O. Barbukhatti, V.A. Porkhanov
Data collection and analysis: S.S. Babeshko, D.I. Shumkov
Drafting the article: S.S. Babeshko, Y.P. Samurganov
Statistical analysis: S.S. Babeshko, D.I. Shumkov
Critical revision of the article: S.S. Babeshko, Y.P. Samurganov, K.O. Barbukhatti
Final approval of the version to be published: S.S. Babeshko, Y.P. Samurganov, D.I. Shumkov, K.O. Barbukhatti, V.A. Porkhanov

References

  1. Carabello B.A., Paulus W.J. Aortic stenosis. Lancet. 2009;373(9667):956-966. https://doi.org/10.1016/s0140-6736(09)60211-7
  2. Lung B., Baron G., Butchart E.G., Delahaye F., Gohlke-Bärwolf C., Levang O.W., Tornos P., Vanoverschelde J.-L., Vermeer F., Boersma E., Ravaud Ph., Vahanian A. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003;24(13):1231-1243. PMID: 12831818. https://doi.org/10.1016/s0195-668x(03)00201-x
  3. Baumgartner H., Falk V., Bax J.J., De Bonis M., Hamm C., Holm P.J., Iung B., Lancellotti P., Lansac E., Muñoz D.R., Rosenhek R., Sjögren J., Tornos Mas P., Vahanian A., Walther T., Wendler O., Windecker S., Zamorano J.L. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739-2791. PMID: 28886619. https://doi.org/10.1093/eurheartj/ehx391
  4. Collinson J., Henein M., Flather M., Pepper J.R., Gibson D.G. Valve replacement for aortic stenosis in patients with poor left ventricular function: comparison of early changes with stented and steintless valve. Circulation. 1999;100(19 Suppl):II1-5. PMID: 10567270. https://doi.org/10.1161/01.cir.100.suppl_2.ii-1
  5. Connolly H.M., Oh J.K., Orszulak T.A., Osborn S.L., Roger V.L., Hodge D.O., Bailey K.R., Seward J.B., Tajik A.J. Aortic valve replacement for aortic stenosis with severe left ventricular dysfunction. Prognostic indicators. Circulation. 1997;95(10):2395-2400. PMID: 9170402. https://doi.org/10.1161/01.cir.95.10.2395
  6. Morris J.J., Schaff H.V., Mullany C.J., Rastogi A., McGregor C.G., Daly R.C., Frye R.L., Orszulak T.A. Determinants of survival and recovery of left ventricular function after aortic valve replacement. Ann Thorac Surg. 1993;56(1):22-29. PMID: 8328871. https://doi.org/10.1016/0003-4975(93)90398-2
  7. Duarte I.G., Murphy C.O., Kosinski A.S., Jones E.L., Craver J.M., Gott J.P., Guyton R.A. Late survival after valve operation in patients with left ventricular dysfunction. Ann Thorac Surg. 1997;64(4):1089-1095. PMID: 9354533. https://doi.org/10.1016/s0003-4975(97)00800-x
  8. Lund O., Flo C., Jensen F.T., Emmertsen K., Nielsen T.T., Rasmussen B.S., Hansen O.K., Pilegaard H.K., Kristensen L.H. Left ventricular systolic and diastolic function in aortic stenosis. Prognostic value after valve replacement and underlying mechanisms. Eur Heart J. 1997;18(12):1977-1987. PMID: 9447328. https://doi.org/10.1093/oxfordjournals.eurheartj.a015209
  9. McCarthy P.M. Aortic valve surgery in patients with left ventricular dysfunction. Semin Thorac Cardiovasc Surg. 2002;14(2):137-143. PMID: 11988952. https://doi.org/10.1053/stcs.2002.32368
  10. Ciesla-Dul M., Pfitzner R., Drwila R., Górkiewicz-Kot I., Sadowski J. Low ejection fraction as risk factor after aortic valve replacement. Przegl Lek. 2004;61(6):579-584. PMID: 15724639.
  11. Lang R.M., Bierig M., Devereux R.B., Flachskampf F.A., Foster E., Pellikka P.A., Picard M.H., Roman M.J., Seward J., Shanewise J.S., Solomon S.D., Spencer K.T., Sutton M. St J., Stewart W.J., Chamber Quantification Writing Group, American Society of Echocardiography's Guidelines and Standards Committee, European Association of Echocardiography. Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440-1463. PMID: 16376782. https://doi.org/10.1016/j.echo.2005.10.005
  12. Flores-Marín A., Gómez-Doblas J., Caballero-Borrego J., Cabrera-Bueno F., Rodríguez-Bailón I., Melero J.M., Porras C., Sánchez-Espín G., Such M., Olalla E., de Teresa E. Long-term predictors of mortality and functional recovery after aortic valve replacement for severe aortic stenosis with left ventricular dysfunction. Rev Esp Cardiol. 2010;63(1):36-45. PMID: 20089224. https://doi.org/10.1016/s1885-5857(10)70007-4
  13. Levy D., Garrison R.J., Savage D.D., Kannel W.B., Castelli W.P. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med. 1990;322(22):1561-1566. PMID: 2139921. https://doi.org/10.1056/nejm199005313222203
  14. Gaasch W.H., Zile M.R., Hoshino P.K., Weinberg E.O., Rhodes D.R., Apstein C.S. Tolerance of the hypertrophic heart to ischemia: studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990;81(5):1644-1653. PMID: 2139593. https://doi.org/10.1161/01.cir.81.5.1644
  15. Marcus M.L., Doty D.B., Hiratzka L.F., Wright C.B., Eastham C.L. Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med. 1982;307(22):1362-1366. PMID: 6215582. https://doi.org/10.1056/nejm198211253072202
  16. Breisch E.A., White F.C., Bloor C.M. Myocardial characteristics of pressure overload hypertrophy: a structural and functional study. Lab Invest. 1984;51(3):333-342. PMID: 6236333.
  17. Rajappan K., Rimoldi O.E., Camici P.G., Bellenger N.G., Pennell D.J., Sheridan D.J. Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis. Circulation. 2003;107(25):3170-3175. PMID: 12796134. https://doi.org/10.1161/01.cir.0000074211.28917.31
  18. Gould K.L., Carabello B.A. Why angina in aortic stenosis with normal coronary arteriograms? Circulation. 2003;107(25):3121-3123. PMID: 12835405. https://doi.org/10.1161/01.cir.0000074243.02378.80
  19. Zile M.R., Brutsaert D.L. New concepts in diastolic dysfunction and diastolic heart failure: part II: Causal mechanisms and treatment. Circulation. 2002;105(12):1503-1508. PMID: 11914262. https://doi.org/10.1161/hc1202.105290
  20. Dweck M.R., Boon N.A., Newby D.E. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol. 2012;60(19):1854-1863. PMID: 23062541. https://doi.org/10.1016/j.jacc.2012.02.093
  21. Hess O.M., Ritter M., Schneider J., Grimm J., Turina M., Krayenbuehl H.P. Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement. Circulation. 1984;69(5):855-865. PMID: 6231136. https://doi.org/10.1161/01.cir.69.5.855
  22. Gunther S., Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation. 1979;59(4):679-688. PMID: 154367. https://doi.org/10.1161/01.cir.59.4.679
  23. Ross J.Jr., Braunwald E. Aortic stenosis. Circulation. 1968;38(1 Suppl):61-67. PMID: 4894151. https://doi.org/10.1161/01.cir.38.1s5.v-61
  24. Шматов Д.В., Железнев С.И., Астапов Д.А., Назаров В.М., Кливер Е.Э., Клинкова А.С., Порушничак Д.Е., Караськов А.М. Непосредственные результаты протезирования аортального клапана у пациентов с аортальным стенозом и систолической дисфункцией левого желудочка. Патология кровообращения и кардиохирургия. 2010;14(4):17-22. [Shmatov D.V., Zheleznev S.I., Astapov D.A., Nazarov V.M., Kliver E.E., Klinkova A.S., Porushnichak D.E., Karaskov A.M. Aortic valve replacement for aoric stenosis in patients with left ventricle systolic dysfunction: immediate resuts. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2010;14(4):17-22. (In Russ.)]
  25. Green G.R., Miller D.G. Continuing dilemmas concerning aortic valve replacement in patients with advanced left ventricular systolic dysfunction. J Heart Valve Dis. 1997;6(6):562-579. PMID: 9427121.
  26. Brogan W.C., Grayburn P.A., Lange R.A., Hillis L.D. Prognosis after valve replacement in patients with severe aortic stenosis and a low transvalvular pressure gradient. J Am Coll Cardiol. 1993;21(7):1657-1660. PMID: 8496533. https://doi.org/10.1016/0735-1097(93)90383-c
  27. Иванов В.А., Евсеев Е.П., Айдамиров Я.А. Результаты протезирования при стенозе аортального клапана у пациентов со сниженной сократительной способностью миокарда левого желудочка. Кардиология и сердечно-сосудистая хирургия. 2016;9(5):52-57. [Ivanov V.A., Evseev E.P., Aidamirov Ya.A. The outcomes of aortic valve replacement in patients with aortic stenosis and reduced left ventricular contractility. Russian Journal of Cardiology and Cardiovascular Surgery. 2016;9(5):52-57. (In Russ.)] https://doi.org/10.17116/kardio20169552-57
  28. Bevilacqua S., Gianetti J., Ripoli A., Paradossi U., Cerilo A.G., Glauber M., Matteucci M.L., Senni M., Gamba A., Quaini E., Ferrazzi P. Aortic valve disease with severe ventricular dysfunction: stentless valve for better recovery. Ann Thorac Surg. 2002;74(6):2016-2021. PMID: 12643389. https://doi.org/10.1016/s0003-4975(02)03981-4
  29. Мехтиев Э.К., Семеновский М.Л., Попцов В.Н., Вавилов П.А, Евлюхин Д.В. Оптимизация хирургического лечения больных с аортальными пороками и выраженной систолической дисфункцией левого желудочка. Вестник трансплантологии и искусственных органов. 2011;13(3):33-40 [Mekhtiev E.K., Semenovsky M.L., Poptsov V.N., Vavilov P.A., Evlyukhin D.V. Optimization of surgical treatment of patients with aortic valve diseases and severe left ventricular systolic dysfunction. Russian Journal of Transplantology and Artificial Organs. 2011;13(3):33-40. (In Russ.)]
  30. Rediker D.E., Boucher C.A., Block P.C., Akins C.W., Buckley M.J., Fifer M.A. Degree of reversibility of left ventricular systolic dysfunction after aortic valve replacement for isolated aortic valve stenosis. Am J Cardiol. 1987;60(1):112-118. PMID: 3604924. https://doi.org/10.1016/0002-9149(87)90996-9
  31. Carabello B.A., Green L.H., Grossman W., Cohn L.H., Koster K., Collins Jr. J.J. Hemodynamic determinants of prognosis of aortic valve replacement in critical aortic stenosis and advanced congestive heart failure. Circulation. 1980;62(1):42-48. PMID: 7379284. https://doi.org/10.1161/01.cir.62.1.42
  32. Ranucci M., Frigiola A., Menicanti L., Castelvecchio S., de Vincentiis C., Pistuddi V. Aortic cross-clamp time, new prostheses, and outcome in aortic valve replacement. J Heart Valve Dis. 2012;21(6):732-739. PMID: 23409353.