Long-term outcomes of off-pump minimally invasive coronary artery bypass grafting of the left anterior descending artery
Published 2020-09-30
Keywords
- MIDCAB,
- minimally invasive coronary artery bypass grafting,
- off-pump coronary artery bypass grafting
How to Cite
Copyright (c) 2020 Shabaev I.F., Kozyrin K.A., Tarasov R.S.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Aim. To evaluate the long-term results of off-pump minimally invasive direct coronary artery bypass grafting (MIDCAB) of the left anterior descending artery (LAD).
Methods. From 2011 to 2017, 146 patients with stable coronary artery disease and hemodynamically significant LAD disease who underwent minimally invasive coronary artery bypass grafting of the left internal mammary artery (LIMA) to the LAD were enrolled in this single-centre prospective study. Patients with significant stenosis of the left main coronary artery and those referred to a concomitant cardiac surgery were excluded. Of the 146 patients, 31 (19.8%) were lost to follow up. The average follow-up duration was 31.4 ± 20.9 mon. The study endpoints included death, myocardial infarction (MI), stroke, repeated myocardial revascularisation, and delayed wound healing.
Results. The rate of fatal outcomes within the follow-up period was 6% (n = 7). The MI incidence rate was 2.6% (n = 3). Of the three MIs, one was fatal. Stroke was registered in 6% (n = 7) of the patients. In one case, the stroke was fatal; 1.2% (n = 2) of the patients required repeat PCI with stenting. The length of stay in the intensive care unit following the index surgery was 1.0 ± 0.2 d. Total 108 (73.9%) patients were discharged within 10 d. There were no complications of delayed wound healing.
Conclusion. Thus, an analysis of the long-term treatment results (31.4 ± 20.9 months) showed satisfactory outcomes in patients with isolated LAD and multivascular coronary atherosclerosis, comparable to the results of standard coronary artery bypass grafting techniques. The survival rate of the patients was 94%, which, combined with the absence of wound complications in the hospital and the long-term follow-up period, provides evidence in favour of more active use of the MIDCAB technology as a popular option that allows successful revascularisation of the myocardium with minimally invasive access and off-pump technologies.
Received 16 April 2020. Revised 28 May 2020. Accepted 29 May 2020.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
References
- Jeremias A., Kaul S., Rosengart T.K., Gruberg L, Brown D.L. The impact of revascularization on mortality in patients with nonacute coronary artery disease. Am J Med. 2009;122(2):152-161. PMID: 19185092. http://dx.doi.org/10.1016/j.amjmed.2008.07.027
- Velazquez E.J., Lee K.L., Jones R.H., Al-Khalidi H.R., Hill J.A., Panza J.A., Michler R.E., Bonow R.O., Doenst T., Petrie M.C., Oh J.K., She L., Moore V.L., Desvigne-Nickens P., Sopko G., Rouleau J.L., STICHES Investigators. Coronary-artery bypass surgery in patients with ischemic cardiomyopathy. N Engl J Med. 2016;374(16):1511-1520. PMID: 27040723, PMCID: PMC4938005. http://dx.doi.org/10.1056/NEJMoa1602001
- Ricotta J.J., Wall L.P., Blackstone E. The influence of concurrent carotid endarterectomy on coronary bypass: a case-controlled study. J Vasc Surg. 2005;41(3):397-401. PMID: 15838469. http://dx.doi.org/10.1016/j.jvs.2004.11.035
- Kon Z.N., Brown E.N., Tran R., Joshi A., Reicher B., Grant M.C., Kallam S., Burris N., Connerney I., Zimrin D., Poston R.S. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. J Thorac Cardiovasc Surg. 2008;135:367-375. PMID: 18242270, PMCID: PMC2962576. http://dx.doi.org/10.1016/j.jtcvs.2007.09.025
- Sandoval Y., Brilakis E.S., Canoniero M., Yannopoulos D., Garcia S. Complete versus incomplete coronary revascularization of patients with multivessel coronary artery disease. Curr Treat Options Cardiovasc Med. 2015;17(3):366. PMID: 25708977. http://dx.doi.org/10.1007/s11936-015-0366-1
- Prestipino F., Spadaccio C., Nenna A., Sutherland F.Wh., Beattie G.W., Lusini M., Nappi F., Chello M. Off-pump coronary artery bypass grafting versus optimal medical therapy alone: effectiveness of incomplete revascularization in high risk patients. J Geriatr Cardiol. 2016;13(1):23-30. PMID: 26918009, PMCID: PMC4753008. http://dx.doi.org/10.11909/j.issn.1671-5411.2016.01.008
- Head S.J., Borgermann J., Osnabrugge R.L.J., Kieser T.M., Falk V., Taggart D.P., Puskas J.D., Gummert J.F., Kappetein A.P. Coronary artery bypass grafting: Part 2 –optimizing outcomes and future prospects. Eur Heart J. 2013;34(37):2873-2886. PMID: 24086086. http://dx.doi.org/10.1093/eurheartj/eht284
- Blazek S., Rossbach C., Borger M.A., Fuernau G., Desch S., Eitel I., Stiermaier T., Lurz P., Holzhey D., Schuler G., Mohr F.-W., Thiele H. Comparison of sirolimus-eluting stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: 7-year follow-up of a randomized trial. JACC Cardiovasc Interv. 2015;8(1 Pt A):30-38. PMID: 25499302. http://dx.doi.org/10.1016/j.jcin.2014.08.006
- Deppe A.-C., Liakopoulos O.J., Kuhn E.W., Slottosch I., Scherner M., Choi Y.-H., Rahmanian P.B., Wahlers T. Minimally invasive direct coronary bypass grafting versus percutaneous coronary intervention for single-vessel disease: A meta-analysis of 2885 patients. Eur J Cardiothorac Surg. 2015;47(3):397-406. PMID: 25100715. http://dx.doi.org/10.1093/ejcts/ezu285
- Wang X.-W., Qu C., Huang C., Xiang X.-Y., Lu Z.-Q. Minimally invasive direct coronary bypass compared with percutaneous coronary intervention for left anterior descending artery disease: A meta-analysis. J Cardiothorac Surg. 2016;11(1):125. PMID: 27491539, PMCID: PMC4974706. http://dx.doi.org/10.1186/s13019-016-0512-1
- Neumann F.-J., Sousa-Uva M., Ahlsson A., Alfonso F., Banning A.P., Benedetto U., Byrne R.A., Collet J.-P., Falk V., Head S.J., Jüni P., Kastrati A., Koller A., Kristensen S.D., Niebauer J., Richter D.J., Seferovic P.M., Sibbing D., Stefanini G.G., Windecker S., Yadav R., Zembala M.O., ESC Scientific Document Group. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87-165. PMID: 30165437. http://dx.doi.org/10.1093/eurheartj/ehy394
- Шабаев И.Ф., Тарасов Р.С., Козырин К.А. Госпитальные результаты миниинвазивного коронарного шунтирования передней нисходящей артерии на работающем сердце. Комплексные проблемы сердечно-сосудистых заболеваний. 2019;8(2):58-67. [Shabaev I.F., Tarasov R.S., Kozyrin K.A. In-hospital results of minimally invasive off-pump coronary artery bypass grafting. Complex Issues of Cardiovascular Diseases. 2019;8(2):58-67. (In Russ.)]
- Sellke F.W., DiMaio J.M., Caplan L.R., Ferguson T.B., Gardner T.J., Hiratzka L.F., Isselbacher E.M., Lytle B.W., Mack M.J., Murkin J.M., Robbins R.C., American Heart Association. Comparing on-pump and off-pump coronary artery bypass grafting: numerous studies but few conclusions: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia in collaboration with the Interdisciplinary Working Group on Quality of Care and Outcomes Research. Circulation. 2005;111(21):2858-2864. PMID: 15927994. http://dx.doi.org/10.1161/CIRCULATIONAHA.105.165030
- Parolari A., Alamanni F., Cannata A., Naliato M., Bonati L., Rubini P., Veglia F., Tremoli E., Biglioli P. Off-pump versus on-pump coronary artery bypass: Meta-analysis of currently available randomized trials. Ann Thorac Surg. 2003;76(1):37-40. PMID: 12842509. http://dx.doi.org/10.1016/s0003-4975(03)00183-8
- Ascione R., Ghosh A., Reeves B.C., Arnold J., Potts M., Shah A., Angelini G.D. Retinal and cerebral microembolization during coronary artery bypass surgery: a randomized, controlled trial. Circulation. 2005;112(25):3833-3838. PMID: 16365207. http://dx.doi.org/10.1161/CIRCULATIONAHA.105.557462
- Murkin J.M., Boyd W.D., Ganapathy S., Adams S.J., Peterson R.C. Beating heart surgery: why expect less central nervous system morbidity. Ann Thorac Surg. 1999;68(4):1498-1501. PMID: 10543553. http://dx.doi.org/10.1016/s0003-4975(99)00953-4
- Shroyer A.L., Grover F.L., Hattler B., Collins J.F., McDonald G.O., Kozora E., Lucke J.C., Baltz J.H., Novitzky D., Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group. On-pump versus off-pump coronary-artery bypass surgery. N Eng J Med. 2009;361(19):1827-1837. PMID: 19890125. http://dx.doi.org/10.1056/NEJMoa0902905
- Lamy A., Devereaux P.J., Prabhakaran D., Taggart D.P., Hu S., Paolasso E., Straka Z., Piegas L.S., Akar A.R., Jain A.R., Noiseux N., Padmanabhan C., Bahamondes J.-C., Novick R.J., Vaijyanath P., Reddy S.K., Tao L., Olavegogeascoechea P.A., Airan B., Sulling T.-A., Whitlock R.P., Ou Y., Pogue J., Chrolavicius S., Yusuf S., CORONARY Investigators. Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year. N Eng J Med. 2013;368:1179-1188. PMID: 23477676. http://dx.doi.org/10.1056/NEJMoa1301228
- Ганюков В.И., Тарасов Р.С., Шилов А.А., Кочергин Н.А., Барбараш Л.С. Миниинвазивная гибридная реваскуляризация миокарда при многососудистом поражении коронарного русла. Состояние вопроса. Мнение научно-исследовательского института комплексных проблем сердечно-сосудистых заболеваний. Комплексные проблемы сердечно-сосудистых заболеваний. 2016;5(2):46-50. [Ganyukov V.I., Tarasov R.S., Shilov A.A., Kochergin N.A., Barbarash L.S. Hybrid minimally invasive myocardial revascularization in multivessel coronary disease. State of the issue. The experience of state research institute. Complex Issues of Cardiovascular Diseases. 2016;5(2):46-50. (In Russ.)]
- Birla R., Patel P., Aresu G., Asimakopoulos G. Minimally invasive direct coronary artery bypass versus off-pump coronary surgery through sternotomy. Ann R Coll Surg Engl. 2013;95(7):481-485. PMID: 24112493, PMCID: PMC5827271. http://dx.doi.org/10.1308/003588413X13629960047119
- Kon Z.N., Brown E.N., Tran R., Joshi A., Reicher B., Grant M.C., Kallam S., Burris N., Connerney I., Zimrin D., Poston R.S. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. J Thorac Cardiovasc Surg. 2008;135(2):367-375. PMID: 18242270, PMCID: PMC2962576. http://dx.doi.org/10.1016/j.jtcvs.2007.09.025
- Murphy G.J., Bryan A.J., Angelini G.D. Hybrid Coronary Revascularization in the Era of Drug-Eluting Stents. Ann Thorac Surg. 2004;78(5):1861-1867. PMID: 15511503. http://dx.doi.org/10.1016/j.athoracsur.2004.07.024
- Stanbridge R.D., Hadjinikolaou L.K. Technical adjuncts in beating heart surgery comparison of MIDCAB to off-pump sternotomy: a meta-analysis. Eur J Cardiothorac Surg. 1999;16(Suppl 2):S24-S33. PMID: 10613552
- Karpuzoglu O.E., Ozay B., Sener T., Aydin N.B., Ketenci B., Aksu T., Gercekoglu H., Demirtas M. Comparison of minimally invasive direct coronary artery bypass and off-pump coronary artery bypass in single-vessel disease. Heart Surg Forum. 2009;12(1):E39-E43. PMID: 19233764. http://dx.doi.org/10.1532/HSF98.20081068
- Kofidis T., Emmert M.Y., Paeschke H.G., Emmert L.S., Zhang R., Haverich A. Long-term follow-up after minimal invasive direct coronary artery bypass grafting procedure: a multi-factorial retrospective analysis at 1000 patient-years. Interact Cardiovasc Thorac Surg. 2009;9(6):990-994. PMID: 19734173. http://dx.doi.org/10.1510/icvts.2009.213900
- Зеньков А.А., Островский Ю.П. Сравнительный анализ ближайших и среднесрочных отдаленных результатов миниинвазивного коронарного шунтирования в случайных выборках пациентов. Грудная и сердечно-сосудистая хирургия. 2014;6:22-28. [Zenkov A.A., Ostrovsky Yu.P. Comparative analysis of the immediate and mid-term results of the minimally invasive coronary artery bypass grafting in random samples of patients. Grudnaya i serdechno-sosudistaya khirurgiya = Breast and cardiovascular surgery. 2014;6:22-28 (In Russ.)]
- Бокерия Л.А., Коваленко О.А., Ирасханов А.К., Бенделиани Н.Г. Сравнительные отдаленные результаты полного артериального коронарного шунтирования и реваскуляризации внутренней грудной артерией и венами. Бюллетень НЦССХ им. А.Н. Бакулева РАМН. Сердечно-сосудистые заболевания. 2012;13(2):49-57. [Bokeria L.A., Kovalenko O.A., Iraskhanov A.K., Bendeliani N.G. Comparative long-term results of complete arterial coronary artery bypass grafting and revascularization with the internal thoracic artery and veins. Byulleten' NTSSSKH im. A.N. Bakuleva RAMN. Serdechno-sosudistyye zabolevaniya = Bulletin of the N.N. A.N. Bakuleva RAMS. Cardiovascular diseases. 2012;13(2):49-57. (In Russ.)]
- Зеньков А.А. Анализ качества жизни при различных методах хирургической реваскуляризации миокарда: проспективное рандомизированное исследование MICSREVS. Вестник Витебского государственного медицинского университета. 2018;17(1):68-80. [Zenkov A.A. Life quality analysis on the application of different methods of surgical myocardial revascularization: prospective randomized trial MICSREVS. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta = Vitebsk State Medical University Bulletin. 2018;17(1):68-80. (In Russ.)]
- Зеньков А.А. Кривая обучения при многососудистой миниинвазивной реваскуляризации миокарда. Кардиология в Беларуси. 2018;1:65-83. [Zenkov A.A. Criterion-reference learning curve of multivessel minimally invasive myocardial revascularization. Kardiologiya v Belarusi = Cardiology in Belarus. 2018;1:65-83. (In Russ.)]
