Vol. 24 No. 1 (2020)
REVIEWS

Markers of myocardial damage after radiofrequency ablation of tachyarrhythmia

PDF (Русский)
  • O. Zayfrid,
  • K. Chueva,
  • E. Vasichkina,
  • A. Mikhailov,
  • D. Lebedev,
  • I. Nikitina,
  • R. Tatarskiy
O. Zayfrid
Almazov National Medical Research Centre, Saint Petersburg
Bio
K. Chueva
Almazov National Medical Research Centre, Saint Petersburg
E. Vasichkina
Almazov National Medical Research Centre, Saint Petersburg
A. Mikhailov
Almazov National Medical Research Centre, Saint Petersburg
D. Lebedev
Almazov National Medical Research Centre, Saint Petersburg
I. Nikitina
Almazov National Medical Research Centre, Saint Petersburg
R. Tatarskiy
Almazov National Medical Research Centre, Saint Petersburg
DOI: https://doi.org/10.21688/1681-3472-2020-1-9-17

Published 2020-04-07

Keywords

  • biochemical marker,
  • cardiac troponin,
  • myoglobin,
  • myocardial damage,
  • radiofrequency ablation,
  • tachyarrhythmia
    • ...More
    Less

How to Cite

Zayfrid, O., Chueva, K., Vasichkina, E., Mikhailov, A., Lebedev, D., Nikitina, I., & Tatarskiy, R. (2020). Markers of myocardial damage after radiofrequency ablation of tachyarrhythmia. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 24(1), 9–17. https://doi.org/10.21688/1681-3472-2020-1-9-17

Copyright (c) 2020 Zayfrid O.L., Chueva K.A., Vasichkina E.S., Mikhailov A.V., Lebedev D.S., Nikitina I.L., Tatarskiy R.B.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

This study presents literature data over the past few years on markers of acute myocardial damage after radiofrequency ablation. Information on markers such as troponin I and T, creatine phosphokinase and its fractions, CRP and interleukins and myoglobin is presented in detail. For each potential myocardial damage indicator, data related to their expression site, chemical basis of each marker and correlation between the degree of damage caused by radiofrequency exposure and the levels of various biomarkers of myocardial damage are provided.

Received 12 November 2019. Revised 26 February 2020. Accepted 27 February 2020.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.

Author contributions
Conception and study design: O.L. Zajfrid, R.B. Tatarsky, E.S. Vasichkina
Drafting the article: O.L. Zajfrid, K.A. Chueva, A.V. Mikhailov
Critical revision of the article: O.L. Zajfrid, R.B. Tatarsky, E.S. Vasichkina, I.L. Nikitina, D.S. Lebedev
Final approval of the version to be published: O.L. Zajfrid, K.A. Chueva, E.S. Vasichkina, A.V. Mikhailov, D.S. Lebedev, I.L. Nikitina, R.B. Tatarsky

PDF (Русский)

References

  1. Hindricks G. Multicentre European Radiofrequency Survey (MERFS) Investigators of the Working Group on Arrhythmias of the European Society of Cardiology. The Multicentre European Radiofrequency Survey (MERFS): complications of radiofrequency catheter ablation of arrhythmias. Eur Heart J. 1993;14(12):1644-53. PMID: 8131762. https://doi.org/10.1093/eurheartj/14.12.1644
  2. Katritsis D.G., Boriani G., Cosio F.G., Jais P., Hindricks G., Josephson M.E., Keegan R., Knight B.P., Kuck K.H., Lane D.A., Lip G.Y., Malmborg H., Oral H., Pappone C., Themistoclakis S., Wood K.A., Young-Hoon K., Lundqvist C.B. Executive Summary: European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias: Endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE). Arrhythm Electrophysiol Rev. 2016;5(3):210-224. PMID: 28116087, PMCID: PMC5248663. https://doi.org/10.15420/aer.2016:5.3.GL1
  3. Priori S.G., Blomström-Lundqvist C., Mazzanti A., Blom N., Borggrefe M., Camm J., Elliott P.M., Fitzsimons D., Hatala R., Hindricks G., Kirchhof P., Kjeldsen K., Kuck K.H., Hernandez-Madrid A., Nikolaou N., Norekvål T.M., Spaulding C., Van Veldhuisen D.J.; ESC Scientific Document Group. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac Death. The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J. 2015;36(41):2793-867. PMID: 26320108. https://doi.org/10.1093/eurheartj/ehv316
  4. Brugada J., N. Blom N., Sarquella-Brugada G., Blomstrom-Lundqvist C., Deanfield J., Janousek J., Abrams D., Bauersfeld U., Brugada R., Drago F., de Groot N., Happonen J.M., Hebe J., Yen Ho S., Marijon E., Paul T., Pfammatter J.P., Rosenthal E.; European Heart Rhythm Association; Association for European Paediatric and Congenital Cardiology. Pharmacological and non–pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace. 2012;15(9):1337-82. PMID: 23851511. https://doi.org/10.1093/europace/eut082
  5. Crosson J.E., Callans D.J., Bradley D.J., Dubin A., Epstein M., Etheridge S., Papez A., Phillips J.R., Rhodes L.A., Saul P., Stephenson E., Stevenson W., Zimmerman F. PACES/HRS expert consensus statement on the evaluation and management of ventricular arrhythmias in the child with a structurally normal heart. Heart Rhythm. 2014;11(9):e55-78. PMID: 24814375. https://doi.org/10.1016/j.hrthm.2014.05.010
  6. Zeng Q., Li X., Xu G. Evaluation of myocardial injury induced by different ablation approaches (radiofrequency ablation versus cryoablation) in atrial flutter patients: a meta-analysis. Biosci Rep. 2019;39(5):BSR20182251. PMCID: PMC6533206, PMID: 31076543. https://doi.org/10.1042/BSR20182251
  7. Bastani H., Drca N., Insulander P., Schwieler J., Braunschweig F., Kennebäck G., Sadigh B., Tapanainen J., Jensen-Urstad M. Cryothermal vs. radiofrequency ablation as atrial flutter therapy: a randomized comparison. Europace. 2012;15(3):420-8. PMID: 22927662. https://doi.org/10.1093/europace/eus261
  8. Carlsson J., Erdogan A., Guettler N., Schulte B., Lay D., Neuzner J., Hamm C.W., Pitschner H.F. Myocardial injury during radiofrequency catheter ablation: comparison of focal and linear lesions. Pacing Clin Electrophysiol. 2001;24(6):962-8. PMID: 11449593. https://doi.org/10.1046/j.1460-9592.2001.00962.x
  9. Kimman G.P., Theuns D., Szili-Torok T., Scholten M.F., Res J.C., Jordaens L.J. CRAVT: a prospective, randomized study comparing transvenous cryothermal and radiofrequency ablation in atrioventricular nodal re-entrant tachycardia. Eur Heart J. 2004;25(24):2232-7. PMID: 15589641. https://doi.org/10.1016/j.ehj.2004.07.008
  10. Madrid A.H., del Rey J.M., Rubí J., Ortega J., González Rebollo J.M., Seara J.G., Ripoll E., Moro C. Biochemical markers and cardiac troponin I release after radiofrequency catheter ablation: approach to size of necrosis. Am Heart J. 1998;136(6):948-55. PMID: 9842005. https://doi.org/10.1016/s0002-8703(98)70148-6
  11. Manolis A.S., Vassilikos V., Maounis T., Melita-Manolis H., Psarros L., Haliasos A., Cokkinos D.V. Detection of myocardial injury during radiofrequency catheter ablation by measuring serum cardiac troponin I levels: procedural correlates. J Am Coll Cardiol. 1999;34:1099-105. PMID: 10520797. https://doi.org/10.1016/s0735-1097(99)00330-7
  12. Katritsis D., Hossein-Nia M., Anastasakis A., Poloniecki I., Holt D.W., Camm A.J., Ward D.E., Rowland E. Use of troponin-T concentration and kinase isoforms for quantitation of myocardial injury induced by radiofrequency catheter ablation. Eur Heart J. 1997;18(6):1007-13.
  13. Линчак Р.М., Догадова Т.В., Свешников А.В., Недбайкин А.М. «Малые повреждения миокарда» при чрескожной катетерной радиочастотной абляции. Вестник Национального медико-хирургического центра им. Н.И. Пирогова. 2010;5(3):111-115. Режим доступа: http://www.pirogov-vestnik.ru/upload/uf/13c/magazine_2010_3.pdf [Linchuk R.M., Dogadova T.V., Sveshnikov A.V., Nedbaikin A.M. Minor myocardium injuries in percutaneous tube radiofrequency ablation. Bulletin of Pirogov National Medical & Surgical Center. 2010;5(3):111-115. (In Russ.)]
  14. Katritsis D.G., Hossein Nia M., Anastasakis A., Poloniecki J., Holt D.W., Camm A.J., Ward D.E., Rowland E. Myocardial injury induced by radiofrequency and low energy ablation: a quantitative study of CK isoforms, CK-MB, and troponin-T concentrations. Pacing Clin Electrophysiol. 1998;21(7):1410-6. PMID: 9670185. https://doi.org/10.1111/j.1540-8159.1998.tb00212.x
  15. Bednarek J., Tomala I., Majewski J., Szczepkowski J., Lelakowski J. Biochemical markers of myocardial damage after radiofrequency ablation. Kardiol Pol. 2004;60(4):335-41. PMID: 15226782.
  16. del Rey J.M., Madrid A.H., Valiño J.M., Rubí J., Mercader J., Moro C., Ripoll E. Cardiac troponin I and minor cardiac damage: biochemical markers in a clinical model of myocardial lesions. Clin Chem. 1998;44(11):2270-6. PMID: 9799753.
  17. Егорова М.О., Голухова Е.З., Теряева Н.Б., Жвания Т.А., Базаев В.А., Круглова М.В. Изменения маркеров повреждения миокарда после радиочастотной абляции у пациентов с аритмиями. Клиническая лабораторная диагностика. 2002;(7):3-5. [Egorova M.O., Golukhova E.Z., Teryaeva N.B., Zhvania T.O., Bazaev V.A., Kruglova M.V. Changes in markers of myocardial damage after radiofrequency ablation in patients with arrhythmias. Clinical Laboratory Diagnostics. 2002;(7):3-5. (In Russ.)]
  18. Brueckmann M., Wolpert C., Bertsch T., Sueselbeck T., Liebetrau C., Kaden J.J., Huhle G., Neumaier M., Borggrefe M., Haase K.K. Markers of myocardial damage, tissue healing, and inflammation after radiofrequency catheter ablation of atrial tachyarrhythmias. J Cardiovasc Electrophysiol. 2004;15(6):686-91. PMID: 15175065. https://doi.org/10.1046/j.1540-8167.2004.03371.x
  19. Ковалев И.А., Мурзина О.Ю., Марцинкевич Г.И., Попов С.В., Свинцова Л.И., Чернышев А.А. Оценка повреждения миокарда при проведении внутрисердечной радиочастотной аблации аритмий у детей и подростков. Педиатрия. Журнал им. Г.Н. Сперанского. 2007;86(2):20-24. Режим доступа: https://pediatriajournal.ru/files/upload/mags/266/2007_2_1272.pdf [Kovalev I.A., Murzina O.Yu., Martsinkevich G.I., Popov S.V., Svintsova L.I., Chernyshev A.A. Assessment of myocardial damage during intracardiac radiofrequency ablation of arrhythmias in children and adolescents. Pediatriya – Zhurnal im G.N. Speranskogo. 2007;86(2):20-23. (In Russ.) Available from: https://pediatriajournal.ru/files/upload/mags/266/2007_2_1272.pdf].
  20. Kannankeril P.J., Pahl E., Wax D.F. Usefulness of troponin I as a marker of myocardial injury after pediatric cardiac catheterization. Am J Cardiol. 2002;90(10):1128-32. PMID: 12423716. https://doi.org/10.1016/s0002-9149(02)02781-9
  21. Vasatova M., Pudil R., Tichy M., Buchler T., Horacek J.M., Haman L., Parizek P., Palicka V. High-sensitivity troponin T as a marker of myocardial injury after radiofrequency catheter ablation. Ann Clin Biochem. 2011;48(1):38-40.
  22. Hirose H., Kato K., Suzuki O., Yoshida T., Oguri M., Yajima K., Hibino T., Yokoi K. Diagnostic accuracy of cardiac markers for myocardial damage after radiofrequency catheter ablation. J Interv Card Electrophysiol. 2006;16(3):169-74. PMID: 17103317. https://doi.org/10.1007/s10840-006-9034-4
  23. Emkanjoo Z., Mottayden M., Givtaj N., Alasti M., Arya A., Haghjoo M., Fazelifar A.F., Alizadeh A., Sadr-Ameli M.A. Evaluation of post-radiofrequency myocardial injury by measuring cardiac troponin I levels. Int J Cardiol. 2007;117(2):173-7. PMID: 16839626. https://doi.org/10.1016/j.ijcard.2006.04.066
  24. Haines D.E., Whayne J.G., Walker J., Nath S., Bruns D.E. The effect of radiofrequency catheter ablation on myocardial creatine kinase activity. J Cardiovasc Electrophysiol. 1995;6(2):79-88. PMID: 7780631. https://doi.org/10.1111/j.1540-8167.1995.tb00760.x
  25. Giannessi D., Piacenti M., Maltinti M., Rossi A., Di Cecco P., Startari U., Cabiati M., Panchetti L., Del Ry S., Morales M.A. Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation. Clin Biochem. 2010;43(15):1241-5. PMID: 20709047. https://doi.org/10.1016/j.clinbiochem.2010.08.003
  26. Pudil R., Parízek P., Tichý M., Haman L., Horáková L., Ulrychová M., Vojácek J., Palicka V. Use of the biochip microarray system in detection of myocardial injury caused by radiofrequency catheter ablation. Clin Chem Lab Med. 2008;46(12):1726-8. PMID: 19055449. . https://doi.org/10.1515/CCLM.2008.341
  27. Полякова И.П., Гукасова И.И., Бокерия Л.А., Ревишвили А.Ш. Электрофизиологические и биохимические маркеры повреждения миокарда при радиочастотной аблации наджелудочковых тахиаритмий у детей. Вестник аритмологии. 2002;(29):5-9. Режим доступа: http://www.vestar.ru/article.jsp?id=545 [Polyakova I.P., Gukasova I.I., Bokeria L.A., Revishvili A.Sh. Electrophysiological and biochemical markers of myocardial damage during radiofrequency ablation of supraventricular tachyarrhythmias in children. Vestnik of Arrhythmology. 2002;(29):5-9. (In Russ.) Available from: http://www.vestar.ru/article.jsp?id=545].
  28. Kızılırmak F., Gokdeniz T., Gunes H.M., Demir G.G., Cakal B., Guler G.B., Guler E., Olgun F.E., Kilicaslan F. Myocardial injury biomarkers after radiofrequency catheter and cryoballoon ablation for atrial fibrillation and their impact on recurrence. Kardiol Pol. 2017;75(2):126-34. PMID: 27221959. https://doi.org/10.5603/KP.a2016.0089
  29. Duman H., Simşek Z., Taş M.H., Gündoğdu F., Değirmenci H., Bakırcı E.M., Demirelli S., Hamur H., Demir O. Effects of radiofrequency ablation on levels of cardiac biochemical markers in patients with atrioventricular nodal re-entry tachycardia. Anadolu Kardiyol Derg = Anatol J Cardiol. 2013;13(7):705-7. PMID: 24084149. https://doi.org/10.5152/akd.2013.229
  30. Nakanishi K., Fukuda S., Yamashita H., Hasegawa T., Kosaka M., Shirai N., Shimada K., Yoshikawa J., Tanaka A. High-sensitive cardiac troponin T as a novel predictor for recurrence of atrial fibrillation after radiofrequency catheter ablation. Europace. 2017;19(12):1951-7. PMID: 28069837. https://doi.org/10.1093/europace/euw314
  31. Tahin T., Herczeg S., Gellér L., Boros A.M., Kovács O.M., Szegedi N., Fórizs É., Szilágyi S., Osztheimer I., Merkely B., Széplaki G. Assessment of the extent of myocardial necrosis following radiofrequency catheter ablation of different supraventricular arrhythmias. Orv Hetil. 2019;160(14):540-8. PMID: 30931601. https://doi.org/10.1556/650.2019.31336
  32. Casella M., Dello Russo A., Russo E., Al-Mohani G., Santangeli P., Riva S., Fassini G., Moltrasio M., Innocenti E., Colombo D., Bologna F., Izzo G., Gallinghouse J.G., Di Biase L., Natale A., Tondo C. Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation. Cardiol J. 2014;21(5):516-23. PMID: 24293166. https://doi.org/10.5603/CJ.a2013.0153
  33. Wójcik M., Kuniss M., Berkowitsch A., Zaltsberg S., Janin S., Wysokiński A., Hamm C.W., Pitschner H.F., Neumann T. Major determinants of myocardial injury after pulmonary vein isolation with radiofrequency ablation. Kardiol Pol. 2012;70(6):549-54. PMID: 22718368.
  34. Shyu K.G, Lin J.L., Chen J.J., Chang H. Use of cardiac troponin T, creatine kinase and its isoform to monitor myocardial injury during radiofrequency ablation for supraventricular tachycardia. Cardiology. 1996;87(5):392-5. PMID: 8894259. https://doi.org/10.1159/000177126
  35. DeLeon-Pennell K.Y., Meschiari C.A., Jung M., Lindsey M.L. Matrix metalloproteinases in myocardial infarction and heart failure. Prog Mol Biol Transl Sci. 2017;147:75-100. PMID: 28413032, PMCID: PMC5576003. https://doi.org/10.1016/bs.pmbts.2017.02.001
  36. Antolic B., Pernat A., Cvijić M., Žižek D., Jan M., Šinkovec M. Radiofrequency catheter ablation versus balloon cryoablation of atrial fibrillation: markers of myocardial damage, inflammation, and thrombogenesis. Wien Klin Wochenschr. 2016;128(13-14):480-7. PMID: 27271554. https://doi.org/10.1007/s00508-016-1002-0
  37. Stein A., Wessling G., Deisenhofer I., Busch G., Steppich B., Estner H., Zrenner B., Schmitt C., Braun S., Schömig A., Ott I. Systemic inflammatory changes after pulmonary vein radiofrequency ablation do not alter stem cell mobilization. Europace. 2008;10(4):444-9. PMID: 18339614. https://doi.org/10.1093/europace/eun041
  38. Li C., Jia L., Wang Z., Niu L., An X. The efficacy of radiofrequency ablation in the treatment of pediatric arrhythmia and its effects on serum IL-6 and hs-CRP. Exp Ther Med. 2017;14(4):3563-8. PMID: 29042948, PMCID: PMC5639399. https://doi.org/10.3892/etm.2017.4960
  39. Chen L., Wei T., Zeng C., Chen Q., Shi Z., Wang L. Effect of radiofrequency catheter ablation on plasma B-type natriuretic peptide. Pacing and Clinical Electrophysiology. 2005;28(3):200-4. PMID: 15733179. https://doi.org/10.1111/j.1540-8159.2005.09386.x
  40. Seiler J., Steven D., Roberts-Thomson K.C., Inada K., Tedrow U.B., Michaud G.F., Stevenson W.G. The effect of open-irrigated radiofrequency catheter ablation of atrial fibrillation on left atrial pressure and B-type natriuretic peptide. Pacing Clin Electrophysiol. 2014;37(5):616-23. PMID: 24372302. https://doi.org/10.1111/pace.12329
  41. Charitakis E., Walfridsson H., Alehagen U. Short-term influence of radiofrequency ablation on NT-proBNP, MR-proANP, Copeptin, and MR-proADM in patients with atrial fibrillation: data from the observational SMURF study. J Am Heart Assoc. 2016;5(9):e003557. PMID: 27633393, PMCID: PMC5079020. https://doi.org/10.1161/JAHA.116.003557
  42. Yanagisawa S., Inden Y., Kato H., Fujii A., Mizutani Y., Ito T., Kamikubo Y., Kanzaki Y., Hirai M., Murohara T. Decrease in B-type natriuretic peptide levels and successful catheter ablation for atrial fibrillation in patients with heart failure. Pacing Clin Electrophysiol. 2016;39(3):225-34. PMID: 26596862. https://doi.org/10.1111/pace.12788
  43. Brueckmann M., Bertsch T., Hoffmann U., Lang S., Kaden J.J., Wolpert C., Huhle G., Borggrefe M., Haase K.K. N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias. Clin Chem Lab Med. 2005;42(8):896-902. PMID: 15387439. https://doi.org/10.1515/CCLM.2004.145
  44. Sacher F., Corcuff J.B., Schraub P., Le Bouffos V., Georges A., Jones S.O., Lafitte S., Bordachar P., Hocini M., Clémenty J., Haissaguerre M., Bordenave L., Roudaut R., Jaïs P. Chronic atrial fibrillation ablation impact on endocrine and mechanical cardiac functions. Eur Heart J. 2008;29(10):1290-5. PMID: 18077441. https://doi.org/10.1093/eurheartj/ehm577
  45. Pillarisetti J., Reddy N., Biria M., Ryschon K., Nagarajan D., Murray C., Atkins D., Bommana S., Reddy M.Y., DiBiase L., Pimentel R., Berenbom L., Dawn B., Natale A., Lakkireddy D. Elevated brain natriuretic peptide level in patients undergoing atrial fibrillation ablation: is it a predictor of failed ablation or a mere function of atrial rhythm and rate at a point in time? J Interv Card Electrophysiol. 2014;40(2):161-8. PMID: 24800931. https://doi.org/10.1007/s10840-014-9898-7
  46. Roy D., Quiles J., Sinha M., Floros D., Gaze D., Collinson P., Baxter G.F., Kaski J.C. Effect of radiofrequency catheter ablation on the biochemical marker ischemia modified albumin. Am J Cardiol. 2004;94(2):234-6. PMID: 15246911. https://doi.org/10.1016/j.amjcard.2004.03.073
  47. Sbarouni E., Georgiadou P., Panagiotakos D., Livanis E.G., Theodorakis G.N., Kremastinos D.T. Ischaemia modified albumin in radiofrequency catheter ablation. Europace. 2007;9(2):127-9. PMID: 17213337. https://doi.org/10.1093/europace/eul176
  48. Nagase H., Woessner J.F. Matrix metalloproteinases. J Biol Chem. 1999;274(31):21491-4. PMID: 10419448. https://doi.org/10.1074/jbc.274.31.21491
  49. Schmidt M., Marschang H., Clifford S., Harald R., Guido R., Oliver T., Johannes B., Daccarett M. Trends in inflammatory biomarkers during atrial fibrillation ablation across different catheter ablation strategies. Int J Cardiol. 2012;158(1):33-8. PMID: 21276621. https://doi.org/10.1016/j.ijcard.2010.12.084
  50. Malmborg H., Christersson C., Lönnerholm S., Blomström-Lundqvist C. Comparison of effects on coagulation and inflammatory markers using a duty-cycled bipolar and unipolar radiofrequency pulmonary vein ablation catheter vs. a cryoballoon catheter for pulmonary vein isolation. Europace. 2013;15(6):798-804. PMID: 23362019. https://doi.org/10.1093/europace/eus411
  51. Herrera Siklódy C., Arentz T., Minners J., Jesel L., Stratz C., Valina C.M., Weber R., Kalusche D., Toti F., Morel O., Trenk D. Cellular damage, platelet activation, and inflammatory response after pulmonary vein isolation: a randomized study comparing radiofrequency ablation with cryoablation. Heart Rhythm. 2012;9(2):189-96. PMID: 21920484. https://doi.org/10.1016/j.hrthm.2011.09.017