Vol. 23 No. 3 (2019)
Endovascular Surgery

Long-term outcomes after bioresorbable scaffold implantation in patients with coronary artery stenosis

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  • A. Prokhorikhin,
  • E. Fartakov,
  • D. Malaev,
  • A. Boykov,
  • V. Baystrukov,
  • I. Grazhdankin,
  • D. Zubarev,
  • E. Kretov
A. Prokhorikhin
Meshalkin National Medical Research Center, Novosibirsk
Bio
E. Fartakov
Meshalkin National Medical Research Center, Novosibirsk
D. Malaev
Meshalkin National Medical Research Center, Novosibirsk
A. Boykov
Meshalkin National Medical Research Center, Novosibirsk
V. Baystrukov
Meshalkin National Medical Research Center, Novosibirsk
I. Grazhdankin
Meshalkin National Medical Research Center, Novosibirsk
D. Zubarev
Almazov National Medical Research Center, Novosibirsk
E. Kretov
Meshalkin National Medical Research Center, Novosibirsk
DOI: https://doi.org/10.21688/1681-3472-2019-3-9-21

Published 2019-11-27

Keywords

  • bioresorbable vascular scaffold,
  • coronary artery disease,
  • coronary stenting,
  • ischemic heart disease,
  • revascularization

How to Cite

Prokhorikhin, A., Fartakov, E., Malaev, D., Boykov, A., Baystrukov, V., Grazhdankin, I., Zubarev, D., & Kretov, E. (2019). Long-term outcomes after bioresorbable scaffold implantation in patients with coronary artery stenosis. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 23(3), 9–21. https://doi.org/10.21688/1681-3472-2019-3-9-21

Copyright (c) 2019 Prokhorikhin A. A., Fartakov E. I., Malaev D. U., Boykov A. A., Baystrukov V. I., Grazhdankin I. O., Zubarev D. D., Kretov E. I.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. The present study aimed to demonstrate the long-term outcomes after Absorb (Abbott Vascular, USA) everolimus-eluting bioresorbable vascular scaffold (BVS) implantation in real-world patients with coronary artery disease.
Methods. This trial involved the largest registry of Absorb BVS implantation in patients with coronary artery disease from Russia, and it was conducted between 2014 and 2018 (n = 500). Safety and efficacy parameters (target vessel failure, defined as a composite of cardiac death, target vessel myocardial infarction and clinically driven target vessel revascularisation; major adverse cardiac and cardiovascular events, defined as a composite of cardiac death, myocardial infarction, target vessel revascularisation and stroke, stent thrombosis according to the Academic Research Consortium definition) were assessed over a period of 2 years after the index procedure.
Results. Lesion treatment success was achieved in 98.51% (n = 594) of patients. In the 2 years after Absorb BVS implantation, long-term outcomes were assessed via phone calls. Only 9.8% (n = 49) of patients were lost to follow-up. The rates of target vessel failure and major adverse cardiac and cerebrovascular events were 11.6% (n = 58) and 12.6% (n = 63), respectively. Definite/probable stent thrombosis was observed in 3.2% (n = 16) of patients.
Conclusion. Using an optimal implantation technique during Absorb BVS implantation in routine clinical practice leads to a high level of lesion treatment success. However, despite this, Absorb BVS use is associated with an increased risk of device-related adverse events, particularly stent thrombosis. Absorb BVS use in long and bifurcated lesions and BVS implantation in the distal segment of the coronary artery are independent predictors of stent thrombosis. In addition, Absorb BVS use in patients with a high functional class of angina and heart failure, multivessel coronary artery disease as well as BVS implantation in the distal segment of the coronary artery are independent predictors of device-related adverse events.

Received 22 July 2019. Revised 1 October 2019. Accepted 14 October 2019.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.

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