Vol. 23 No. 1 (2019)
ANESTHESIOLOGY & RESUSCITATION

Plasma mitochondrial DNA level as an early marker of systemic inflammatory response syndrome and organ failure in patients undergoing cardiac surgery

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  • T. Zabelina,
  • O. Grebenchikov,
  • Yu. Skripkin,
  • A. Yavorovsky,
  • V. Lihvantsev
T. Zabelina
Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
Bio
O. Grebenchikov
Moscow Regional Research and Clinical Institute, Moscow, Russian Federation; V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation
Yu. Skripkin
Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
A. Yavorovsky
Sechenov First Moscow Medical University, Moscow, Russian Federation
V. Lihvantsev
Moscow Regional Research and Clinical Institute, Moscow, Russian Federation; Sechenov First Moscow Medical University, Moscow, Russian Federation
DOI: https://doi.org/10.21688/1681-3472-2019-1-33-41

Published 2019-03-09

Keywords

  • mitochondrial DNA,
  • acute kidney injury,
  • postoperative complication,
  • systemic inflammatory response syndrome

How to Cite

Zabelina, T., Grebenchikov, O., Skripkin, Y., Yavorovsky, A., & Lihvantsev, V. (2019). Plasma mitochondrial DNA level as an early marker of systemic inflammatory response syndrome and organ failure in patients undergoing cardiac surgery. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 23(1), 33–41. https://doi.org/10.21688/1681-3472-2019-1-33-41

Copyright (c) 2019 Zabelina T. S., Grebenchikov O. A., Skripkin Yu. V., Yavorovsky A. G., Lihvantsev V. V.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. To assess whether plasma mitochondrial DNA (mtDNA) levels in the early postoperative period can predict the development of systemic inflammatory response syndrome (SIRS) and multiple organ failure in patients undergoing cardiac surgery.

Methods. This pilot, prospective, observational, cohort study included 85 patients undergoing cardiac surgery. Plasma mtDNA levels were determined immediately after the surgery, and the development of SIRS, acute kidney injury, acute heart failure, and adult respiratory distress syndrome was assessed.

Results. The mtDNA levels showed good potential for predicting the development of SIRS within 1-2 days after the surgery (area under the curve = 0.74). Regarding the cut-off point, a mtDNA level of >0.54 ng/mL predicted the development of SIRS in the early postoperative period with a sensitivity of 73.7% and a specificity of 66%. The odds ratio for the development of acute kidney injury with/without SIRS was 3.4 [confidence interval (CI) = 1.27–9.08; p = 0.0149]; acute heart failure, 5.7 (CI = 2.20–14.84; p = 0.0003); and adult respiratory distress syndrome, 3.6 (CI = 1.01–11.10; p = 0.047).

Conclusion. The plasma mtDNA levels in the early postoperative period can be used as a predictive marker for the development of SIRS and multiple organ failure in patients undergoing cardiac surgery. Moreover, SIRS is associated with the development of acute kidney injury, acute heart failure, and adult respiratory distress syndrome.

Received 25 March 2019. Revised 3 April 2019. Accepted 8 April 2019.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.

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