Vol. 16 No. 1 (2012)
ANESTHESIOLOGY, RESUSCITATION AND PERFUSIOLOGY

Resistance to K. pneumoniae in young children with congenital heart defects

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  • V. Ilina,
  • O. Strunin,
  • O. Solovev,
  • L. Samoylova,
  • Yu. Gorbatykh
V. Ilina
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
O. Strunin
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
O. Solovev
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
L. Samoylova
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
Yu. Gorbatykh
Academician E.N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Bio
DOI: https://doi.org/10.21688/1681-3472-2012-1-57-60

Published 2012-03-28

Keywords

  • K.PNEUMONIAE,
  • RESISTANCE,
  • ANTIBIOTICS,
  • EXTENDED SPECTRUM β-LACTAMASE

How to Cite

Ilina, V., Strunin, O., Solovev, O., Samoylova, L., & Gorbatykh, Y. (2012). Resistance to K. pneumoniae in young children with congenital heart defects. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 16(1), 57–60. https://doi.org/10.21688/1681-3472-2012-1-57-60

Copyright (c) 2012 Ilina V.N., Strunin O.V., Solovev O.N., Samoylova L.M., Gorbatykh Yu.N.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Klebsiella pneumoniae is one of the leading agents of nosocomial infections (NI). In Russia, Klebsiella pneumoniae is the third in frequency of gram-negative pathogen NI. For a long time one of the major clinically relevant mechanisms of acquired resistance to K. pneumoniae is multidrug resistance caused by extended spectrum β-lactamase production (ESBL). Carbapenems show the greatest resistance to the action of ESB. However, now there exist registered strains of K.pneumoniae resistant to carbapenems. In connection with this in 2008 we conducted a prospective study on resistance to K. pneumoniae in young children being treated at ICU. It was found out that resistance to III-IV-generation cephalosporines, fluoroquinolones, aminoglycosides is determined by production of ESBL, while resistance to carbapenems occurs due to reduction of permeability of cell membranes, in combination with production of ESBL. Some features of patients colonized with multidrug-resistant strains of K. pneumoniae are described.

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