Vol. 22 No. 2 (2018)
CORONARY ARTERY DISEASES

Impact of hostility on mortality of patients with coronary artery disease after percutaneous coronary intervention

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  • Georgiy Pushkarev,
  • Vadim Kuznetsov
Georgiy Pushkarev
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
Bio
Vadim Kuznetsov
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
DOI: https://doi.org/10.21688/1681-3472-2018-2-39-46

Published 2018-08-07

Keywords

  • coronary artery disease,
  • hostility,
  • mortality,
  • percutaneous coronary intervention,
  • psychosocial risk factors

How to Cite

Pushkarev, G., & Kuznetsov, V. (2018). Impact of hostility on mortality of patients with coronary artery disease after percutaneous coronary intervention. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 22(2), 39–46. https://doi.org/10.21688/1681-3472-2018-2-39-46

Copyright (c) 2018 Pushkarev G.S., Kuznetsov V.A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. The study focuses on the assessment of associations of hostility with clinical and instrumental variables in patients with coronary artery disease after percutaneous coronary intervention, as well as on its effect on the risk of death for the patients in one year after surgery.
Methods. The prospective study included 1,018 patients with coronary artery disease (764 men and 254 women, mean age 58.9±9.7 years) who had undergone percutaneous coronary intervention. Mean duration of follow-up was 12.0±1.8 months. Hostility was assessed by Russian version of Cook and Medley hostility scale. To investigate the relative risk (RR) of death from all causes and cardiovascular disease was used Cox's multivariate regression model of proportional risk.
Results. The mean score on the Cook-Medley hostility scale was 15.1±3.9. A high level of hostility was observed in 189 patients (20.0%). There was no difference in age, gender and main clinical and instrumental variables between reference group and group of patients with a high level of hostility. No difference was found in echocardiographic parameters and coronary angiographic data between the groups. At admission, acute coronary syndrome was more often observed in patients with a high level of hostility as compared to those in the reference group (39.2% vs. 31.0%, p = 0.03). During the follow-up, 24 patients (2.4%) died from all causes and 21 patients (2.2%) died from cardiovascular disease. Depending on the level of hostility, RR of death from all causes was 1.10 (95% confidence interval [CI] 0.99–1.22, p = 0.09) and 1.12 (95% CI 1.01–1.27, p = 0.04) from cardiac causes. When analyzing categorical indicators, in patients with a high level of hostility, the relative risk of death, both for all causes (RR = 2.65, 95% CI 1.09–6.45, p = 0.03) and cardiovascular disease (RR = 3.38, 95% CI 1.29–8.82, p = 0.01), was significantly higher in comparison with patients in the reference group.
Conclusion. PAcute coronary syndrome was more frequently diagnosed in patients with a high level of hostility. The hostility was significantly and independently associated with the risk of death from cardiovascular disease in patients with coronary artery disease after percutaneous coronary interventions. In patients with high levels of hostility, the risk of all-cause and cardiovascular mortality was significantly higher.

Received 30 May 2018. Revised 5 July 2018. Accepted 9 July 2018.

Funding: The study did not have sponsorship.

Conflict of interest: The authors declare no conflict of interest.

 

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References

  1. Benjamin E.J., Virani S.S., Callaway C.W., Chamberlain A.M., Chang A.R., Cheng S., Chiuve S.E., Cushman M., Delling F.N., Deo R., de Ferranti S.D., Ferguson J.F., Fornage M., Gillespie C., Isasi C.R., Jiménez M.C., Jordan L.C., Judd S.E., Lackland D., Lichtman J.H., Lisabeth L., Liu S., Longenecker C.T., Lutsey P.L., Mackey J.S., Matchar D.B., Matsushita K., Mussolino M.E., Nasir K., O'Flaherty M., Palaniappan L.P., Pandey A., Pandey D.K., Reeves M.J., Ritchey M.D., Rodriguez C.J., Roth G.A., Rosamond W.D., Sampson U.K.A., Satou G.M., Shah S.H., Spartano N.L., Tirschwell D.L., Tsao C.W., Voeks J.H., Willey J.Z., Wilkins J.T., Wu J.H., Alger H.M., Wong S.S., Muntner P.; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2018 Update: a report from the American Heart Association. Circulation. 2018;137(12):e67-e492. PMID: 29386200. http://dx.doi.org/10.1161/CIR.0000000000000558
  2. Оганов Р.Г., Масленникова Г.Я. Демографические тенденции в Российской Федерации: вклад болезней системы кровообращения. Кардиоваскулярная терапия и профилактика. 2012;11(1):5-10. [Oganov R.G., Maslennikova G.Ya. Demographic trends in the Russian Federation: the impact of cardiovascular disease. Cardiovascular Therapy and Prevention. 2012;11(1):5-10. (In Russ.)]
  3. Оганов Р.Г., Масленникова Г.Я. Демографическая ситуация и сердечно-сосудистые заболевания в России: пути решения проблем. Кардиоваскулярная терапия и профилактика. 2007;6(8):7-14. [Oganov R.G., Maslennikova G.Ya. Demographic situation and cardiovascular disease in Russia: problem scope and possible solutions. Cardiovascular Therapy and Prevention. 2007;6(8):7-14. (In Russ.) ]
  4. Pedersen S.S., Lemos P.A., van Vooren P.R., Liu T.K., Daemen J., Erdman R.A., Smits P.C., Serruys P.W., van Domburg R.T. Type-D personality predicts death or myocardial infarction after bare metal stent or sirolimus-eluting stent implantation: a Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital (RESEARCH) registry sub-study. J Am Coll Cardiol. 2004;44:997-1001. PMID: 15337209. http://dx.doi.org/10.1016/j.jacc.2004.05.064
  5. Chida Y., Steptoe A. The association of anger and hostility with future coronary heart disease: A meta-analytic review of prospective evidence. J Am Coll Cardiol. 2009;53:936-46. PMID: 19281923. http://dx.doi.org/10.1016/j.jacc.2008.11.044
  6. Sommer I., Griebler U., Mahlknecht P., Thaler K., Bouskill K., Gartlehner G., Mendis S. Socioeconomic inequalities in non-communicable diseases and their risk factors: an overview of systematic reviews. BMC Public Health. 2015;15:914. PMID: 26385563, PMCID: PMC4575459. http://dx.doi.org/10.1186/s12889-015-2227-y
  7. Perk J., De Backer G., Gohlke H., Graham I., Reiner Z., Verschuren M., Albus C., Benlian P., Boysen G., Cifkova R., Deaton C., Ebrahim S., Fisher M., Germano G., Hobbs R., Hoes A., Karadeniz S., Mezzani A., Prescott E., Ryden L., Scherer M., Syvänne M., Scholte op Reimer W.J., Vrints C., Wood D., Zamorano J.L., Zannad F.; European Association for Cardiovascular Prevention & Rehabilitation (EACPR); ESC Committee for Practice Guidelines (CPG). European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J. 2012;33(13):1635-701. PMID: 22555213. http://dx.doi.org/10.1093/eurheartj/ehs092
  8. Пушкарев Г.С., Кузнецов В.А., Ярославская Е.И., Бессонов И.С. Функциональная социальная поддержка у больных ишемической болезнью сердца, перенесших коронарное стентирование. Сердце: журнал для практикующих врачей. 2017;16 (1):66-72. http://dx.doi.org/10.18087/rhj.2017.1.2274 [Pushkarev G. S., Kuznetsov V.A., Yaroslavskaya E.I., Bessonov I. S. Functional social support for patients with ischemic heart disease after coronary stenting. Russian Heart Journal. 2017;16(1):66-72. (In Russ.) http://dx.doi.org/10.18087/rhj.2017.1.2274].
  9. Пушкарев Г.С. Кузнецов В.А. Ярославская Е.И., Бессонов И.С. Прогностическая роль психосоциальных факторов риска у больных ишемической болезнью сердца, перенесших коронарное стентирование. Кардиология. 2017;57(6):11-15. Режим доступа: https://cardio-journal.ru/ru/archive/article/35087 [Pushkarev G.S., Kuznetsov V.A., Yaroslavskaya E.I., Bessonov I.S. Prognostic significance of psychosocial risk factors in patients with coronary artery disease after percutaneous coronary interventions. Kardiologiia. 2017;57(6):11-15. (In Russ.) Available from: https://cardio-journal.ru/en/archive/article/35087].
  10. Барканова О.В. Методики диагностики эмоциональной сферы. Психологический практикум. Красноярск: Литера-Принт, 2009. 237 с. [Barkanova O.V. Methods of diagnosing of the emotional sphere. Psychological manual. Krasnoyarsk: Litera-Print Publ.; 2009. 237 p. (In Russ.)]
  11. Barefoot J.C., Dodge K.A., Peterson B.L., Dahlstrom W.G., Williams R.B. Jr. The Cook-Medley hostility scale: item content and ability to predict survival. Psychosom Med. 1989;51(1):46-57. PMID: 2928460.
  12. Медик В.А., Токмачев М.С. Математическая статистика в медицине. М.: Финансы и статистика, 2007. 800 с. [Medik V.A., Tokmachev M.S. Mathematical statistics in medicine. Moscow: Finance and Statistics Publ.; 2007. 800 p. (In Russ.)]
  13. Rozanski A., Blumenthal J.A., Davidson K.W., Saab P.G., Kubzansky L. The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol. 2005;45(5):637-51. PMID: 15734605. http://dx.doi.org/10.1016/j.jacc.2004.12.005
  14. Bortman D.J., Golden S.H., Wittstein I.S. The cardiovascular toll of stress. Lancet. 2007;370:1089-100. PMID: 17822755. http://dx.doi.org/10.1016/S0140-6736(07)61305-1
  15. Steptoe A., Cropley M., Griffith J., Kirschbaun C. Job strain and anger expression predict early morning elevations in salivary cortisol. Psychosom Med. 2000;62(2):286-92. PMID: 10772410.
  16. Stewart J.C., Janicki-Deverts D., Muldoon M.F., Kamarck T.W. Depressive symptoms moderate the influence of hostility on serum interleukin-6 and C-reactive protein. Psychosom Med. 2008;70(2):197-204. PMID: 18256345. http://dx.doi.org/10.1097/PSY.0b013e3181642a0b
  17. Pizzi C., Manzoli L., Mancini S., Costa G.M. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J. 2008;29(9):1110-7. PMID: 18400765. http://dx.doi.org/10.1093/eurheartj/ehn137
  18. Everson S.A., Kauhanen J., Kaplan G.A., Goldberg D.E., Julkunen J., Tuomilehto J., Salonen J.T. Hostility and increased risk of mortality and acute myocardial infarction: the mediating role of behavioral risk factors. Am J Epidemiol. 1997;146(2):142-52. PMID: 9230776.
  19. Appleton K.M., Woodside J.V., Arveiler D., Haas B., Amouyel P., Montaye M., Ferrieres J., Ruidavets J.B., Yarnell J.W., Kee F., Evans A., Bingham A., Ducimetiere P., Patterson C.C.; PRIME study group. A role for behavior in the relationships between depression and hostility and cardiovascular disease incidence, mortality, and all-cause mortality: the prime study. Ann Behav Med. 2016;50(4):582-91. PMID: 26979997, PMCID: PMC4933737. http://dx.doi.org/10.1007/s12160-016-9784-x
  20. Kuper H., Marmot M., Hemingway H. Systematic review of prospective cohort studies of psychosocial factors in the aetiology and prognosis of coronary heart disease. Semin Vasc Med. 2002;2(3):267-314. PMID: 16222620. http://dx.doi.org/10.1055/s-2002-35401
  21. Bernstein M.H., Colby S.M., Bidwell L.C., Kahler C.W., Leventhal A.M. Hostility and cigarette use: a comparison between smokers and nonsmokers in a matched sample of adolescents. Nicotine Tob Res. 2014;16(8):1085-93. PMID: 24692670, PMCID: PMC4155423. http://dx.doi.org/10.1093/ntr/ntu033
  22. Christensen U., Lund R., Damsgaard M.T., Holstein B.E., Ditlevsen S., Diderichsen F., Due P., Iversen L., Lynch J. Cynical hostility, socioeconomic position, health behaviors, and symptom load: a cross-sectional analysis in a Danish population-based study. Psychosom Med. 2004;66(4):572-7. PMID: 15272105. http://dx.doi.org/10.1097/01.psy.0000126206.35683.d1
  23. Holt-Lunstad J., Smith T.W., Uchino B.N. Can hostility interfere with the health benefits of giving and receiving social support? The impact of cynical hostility on cardiovascular reactivity during social support interactions among friends. Ann Behav Med. 2008;35:319-30. PMID: 18584266. http://dx.doi.org/10.1007/s12160-008-9041-z
  24. von Känel R. Psychosocial stress and cardiovascular risk : current opinion. Swiss Med Wkly. 2012;142:w13502. PMID: 22271452. http://dx.doi.org/10.4414/smw.2012.13502