Vol. 22 No. 2 (2018)
EXPERIMENTAL STUDIES

Hydrodynamics in the intact and denervated aorta in experiment

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  • Evgeny Petrov,
  • Alexander Tuturov,
  • Dmitry Volov,
  • Koami Kossi-Sogbo
Evgeny Petrov
Samara State Medical University, Samara, Russian Federation
Alexander Tuturov
Samara State Medical University, Samara, Russian Federation
Bio
Dmitry Volov
Samara State Transport University, Samara, Russian Federation
Koami Kossi-Sogbo
Samara State Medical University, Samara, Russian Federation
DOI: https://doi.org/10.21688/1681-3472-2018-2-30-38

Published 2018-08-07

Keywords

  • antiflatter stabilization,
  • aorta,
  • auto oscillations,
  • hydrodynamics,
  • isolated wave

How to Cite

Petrov, E., Tuturov, A., Volov, D., & Kossi-Sogbo, K. (2018). Hydrodynamics in the intact and denervated aorta in experiment. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 22(2), 30–38. https://doi.org/10.21688/1681-3472-2018-2-30-38

Copyright (c) 2018 Petrov E.S., Tuturov A.O., Volov D.B., Kossi-Sogbo K.A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aim. As neurogenic processes affect the cardiovascular system and change its function throughout the whole life, the study aims to simulate and study the hydrodynamics of blood flow in an intact and denervated aorta.
Methods. A pulse wave going through an intact segment of a dog’s thoracic aorta, a denervated autograft, and a donor dog’s thoracic aorta allograft was assessed by using equipment for blood pressure measurement and tensiometry of longitudinal and diametrical deformations of blood vessels at the point of pressure measuring. The experiments were performed under general endotracheal anesthesia. Two series of acute experiments on replacement of the thoracic aorta by an autograft and an allograft were carried out. Each series had eight dogs. The approach was thoracotomy in the IV intercostal space on the left. A required segment was replaced after heparin infusion while using subclavian-femoral bypass and retrograde autoperfusion.
Results. It was found out experimentally that the formation and propagation of a normal isolated pulse wave with preservation of a viscous laminar blood flow were impossible without preserved innervation of the aorta. The experiments showed that in an intact aorta, its diameter tends to increase (by 400–500 μm), with simultaneous shortening of the segment (by 250 μm), and this process keeps being ahead of the pressure wave by 0.02–0.04 s. The rate of aortic dilatation is faster than that of systolic pressure elevation. However, in contrast to the intact aorta, the autograft, on the contrary, becomes longer and narrows, as pressure rises.
Conclusion. To create optimal hydrodynamics of aortic blood flow, there should be a neuroreflectory system to control each pulse wave, which must determine its solitonic nature and provide antiflatter stabilization of blood flow.

Received 16 April 2018. Revised 3 June 2018. Accepted 7 June 2018.

Funding: The study did not have sponsorship.

Conflict of interest: The authors declare no conflict of interest.

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References

  1. Matsuyama A., Takatori S., Sone Y., Ochi E., Goda M., Zamami Y., Hashikawa-Hobara N., Kitamura Y., Kawasaki H. Effect of nerve growth factor on innervation of perivascular nerves in neovasculatures of mouse cornea. Biol Hyarm Bull. 2017;40(4):396-401. PMID: 28381794. http://dx.doi.org/10.1248/bpb.b16-00583
  2. Coote J.H. Landmarks in understanding the central nervous control of the cardiovascular system. Exp Physiol. 2007;92(1):3-18. PMID: 17030558. http://dx.doi.org/10.1113/expphysiol.2006.035378
  3. Швалев В.Н. Тарский Н.А. Феномен ранней возрастной инволюции симпатического отдела вегетативной нервной системы. Кардиология. 2001;(2):10-14. [Shvalev V.N., Tarskij N.A. The phenomenon of early age involution of sympathetic nervous system. Kardiologija. 2001;(2):10-14. (In Russ.)]
  4. Швалев В.Н., Реутов В.П., Рогоза А.Н., Сергиенко В.Б., Аншелес А.А., Ковалев В.П. Развитие современных представлений о нейрогенной природе кардиологических заболеваний. Тихоокеанский медицинский журнал. 2014;55(1):10-14. [Shvalev V.N., Reutov V.P., Rogoza A.N., Sergienko V.B., Ansheles A.A., Kovalev V.P. Development of modern concepts of the neurogenic nature of cardiac diseases. Pacific Medical Journal. 2014;55(1):10-14. (In Russ.)]
  5. Швалев В.Н., Рогоза А.Н., Тарский Н.А., Сергиенко В.Б., Аншелес А.А., Реутов В.П., Юдаев А.А. Внезапная сердечная смерть и морфофункциональная диагностика предшествующих возрастных нейродистрофических изменений организма. Тихоокеанский медицинский журнал. 2017;67(1):42-51. http://dx.doi.org/10.17238/PmJ1609-1175.2017.1.42-51 [Shvalev V.N., Rogoza F.N., Tarsky N.A., Sergienko V.B., Ansheles A.A., Reutov V.P., Yudaev A.A. Sudden cardiac death and morphofunctional diagnostics previous age neurotrophic changes of organisms. Pacific Medical Journal. 2017;67(1):42-51. (In Russ.) http://dx.doi.org/10.17238/PmJ1609-1175.2017.1.42-51]
  6. Hales St. Haemastatics. Механические свойства кровеносных сосудов. В кн.: Джонсон П. Периферическое кровообращение. М.: Медицина, 1982. С. 64-104. [Hales St. Haemastatics. Mechanical properties of blood vessels. In: Johnson P. Peripheral circulation. Moscow: Medicine; 1982. pp. 64-104. (In Russ.)]
  7. Frank O. Die Grundform des arteriellen Pulses. Z f Biol. 1899;37:438-526.
  8. Heyman F. Extra- and intra-arterial records of pulse waves and locally introduced pressure waves. Acta Med Scand. 1959;163(6):473-475. PMID: 13660760.
  9. Heyman F. Rapid reflex interference with peripheral vascular tone. Nature. 1967;216(5113):402-3. PMID: 6053828.
  10. Bauer R.D., Russe R., Schabert A. The relationship between pressure and diameter of arteries in vivo during rhythmic blood pressure changes of second higher orders. Pflugers Arch. 1977;368(1 Suppl.):R7.
  11. Mangel A., Fahim M., van Breeman C. Rhytmic contractile activity of the in vivo rabbit aorta. Nature. 1981;289(5799):692-4. PMID: 7464936.
  12. Петров Е.С., Тутуров А.О., Косси-Согбо К.А. Нерешенные проблемы сосудистых анастомозов. Грудная и сердечно-сосудистая хирургия. 2017;59(6):363-367. http://dx.doi.org/10.24022/0236-2791-2017-59-6-363-367. [Petrov E.S., Tuturov A.O., Kossi-Sogbo K.A. Unsolved problems of vascular anastomoses. Grudnaya i Serdechno-Sosudistaya Khirurgiya = Russian Journal of Thoracic and Cardiovascular Surgery. 2017;59(6):363-367. (In Russ.) http://dx.doi.org/10.24022/0236-2791-2017-59-6-363-367]
  13. Mangel A., Fahim M., van Breeman C. Control of vascular contractility by the cardiac pacemaker. Scence. 1982;215(4540):1627-9. PMID: 7071582.
  14. Sharif H., Hou S. Autonomic dysreflexia: a cardiovascular disorder following spinal cord injury. Neural Regen Res. 2017;12(9):1390-1400. PMCID: PMC5649450; PMID: 29089975. http://dx.doi.org/10.4103/1673-5374.215241
  15. Nardone M., Incognito A.V., Millar P.J. Evidence for pressure-independent sympathetic modulation of central pulse wave velocity. J Am Heart Assoc. 2018;7(3). PMID: 29378730; PMCID: PMC5850264. http://dx.doi.org/10.1161/JAHA.117.007971
  16. Кошев В.И., Петров Е.С., Пирогов В.П., Иванова В.Д., Волобуев А.Н. Эволюция механизмов управления гидродинамикой кровообращения. В кн.: Клиническая анатомия и экспериментальная хирургия. Ежегодник Российской ассоциации клинических анатомов. 2001;1:43-46. [Koshev V.I., Petrov E.S., Pirogov V.P., Ivanova V.D., Volobuev A.N. Evolution of the mechanisms controlling the hydrodynamics of blood circulation. In: Clinical Anatomy and Experimental Surgery. Year-book of the Russian Association of Clinical Anatomy. 2001;1:43-46. (In Russ.)]
  17. Caro C.G., Cybulski G., Darrow R.D. Pre-systolie flow reversal in the femoral artery in healthy young mendetected by magnetic resonance imaging: possible association with isovolumic cardiac contraction. J Physiol. 1993;473:205.
  18. van Disseldorp E.M., Petterson N.J., Rutten M.C., van de Vosse F.N., van Sambeek M.R., Lopata R.G. Patient specific wall stress analysis and mechanical characterization of abdominal aortic aneurysms using 4D ultrasound. Eur J Vasc Endovasc Surg. 2016;52(5):635-642. PMID: 27665991. http://dx.doi.org/10.1016/j.ejvs.2016.07.088
  19. Liu X., Peng C., Xia Y., Gao Z., Xu P., Wang X., Xian Z., Yin Y., Jiao L., Wang D., Shi L., Huang W., Liu X., Zhang H. Hemodynamics analysis of the serial stenotic coronary arteries. Biomed Eng Online. 2017;16(1):127. PMCID: PMC5679505; PMID: 29121932. http://dx.doi.org/10.1186/s12938-017-0413-0
  20. Кошев В.И., Петров Е.С., Волобуев А.Н. Роль артерий в антифлаттерной стабилизации потока крови. Вестник Российской академии медицинских наук. 2007;62(6):12-17. [Koshev V.I., Petrov Ye.S., Volobuyev A.N. Arterial activity and antiflutter stabilization of blood stream. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian academy of medical sciences. 2007;62(6):12-17. (In Russ.)]
  21. Lannoy M., Slove S., Jacob M.P. The function of elastic fibers in the arteries: beyond elasticity. Pathol Biol (Paris). 2014;62(2):79-83. PMID: 24679588. http://dx.doi.org/10.1016/j.patbio.2014.02.011
  22. Bozeler E. Conduction automaticity and tonus of visceral muscle. Experientia. 1948;4(6):213-8. PMID: 18869660.
  23. Кошев В.И., Петров Е.С., Волобуев А.Н. Гидродинамический флаттер и антифлаттерная стабилизация в сердечно-сосудистой системе: гидродинамическая модель и общая теория кровообращения. Самара: Офорт, 2007. 407 с. [Koshev V.I., Petrov E.S., Volobuev A.N. Hydrodynamic flutter and antiflatter stabilization in the cardiovascular system: Hydrodynamic model and the general theory of blood circulation. Samara: Ofort Publ, 2007. 407 p. (In Russ.)]