Vol. 22 No. 2 (2018)
REVIEWS

On the question of the antiproliferative coating of coronary stents

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  • Alexander Digay
Alexander Digay
Goldberg Research Institute of Pharmacology and Regenerative Medicine, branch of Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
Bio
DOI: https://doi.org/10.21688/1681-3472-2018-2-22-29

Published 2018-08-07

Keywords

  • drug eluting coronary stents,
  • everolimus,
  • novolimus,
  • pharmacodynamics,
  • sirolimus,
  • zotarolimus
    • ...More
    Less

How to Cite

Digay, A. (2018). On the question of the antiproliferative coating of coronary stents. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 22(2), 22–29. https://doi.org/10.21688/1681-3472-2018-2-22-29

Copyright (c) 2018 Digay A. M.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The article looks at the issue of antiproliferative coatings of drug eluting coronary stents from a perspective of their pharmacological properties. Antiproliferative drugs from the “limus” group used in coronary stents do not have decisive advantages over each other. This statement is based on the same pharmacological nature of drugs of the rapamycin group. Regardless of the technology of their creation and the indications for medical use, these drugs have absolutely the same mechanism of pharmacological effects. Currently, all available preparations from the "limus" group satisfy the required pharmacodynamic parameters to achieve a delayed clinical effect in coronary stenting. The coronary stent classification supposes their ranking only by the platform and the eluting system, without taking into account the type of antiproliferative drugs.

Received 13 March 2018. Revised 17 April 2018. Accepted 23 April 2018.

Funding: The study did not have sponsorship.

Conflict of interest: The author declares no conflict of interest.

PDF (Русский)

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