Published 2018-04-02
Keywords
- carotid endarterectomy,
- acute ischemic stroke,
- emergency brain revascularization
How to Cite
Copyright (c) 2018 Kazantsev A.N., Burkov N.N., Tarasov R.S., Anufriev A.I., Shabaev A.R., Ruban E.V., Mironov A.V., Heraskov V.Yu.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Currently, there are no clear domestic and foreign recommendations for cerebral revascularization, also missing is a definite decision on determining the timing and possibility of carotid endarterectomy in acute ischemic stroke. A set of measures aiming at obtaining a satisfactory outcome of carotid endarterectomy in the acute ischemic cerebrovascular event is developed. To prevent hyperperfusion complications, a temporary shunt, low doses of unfractionated heparin, adequate antiplatelet, hypotensive and lipid-lowering therapy are used. The main advantages and disadvantages of all modern methods of surgical treatment of this condition are presented.
Received 22 August 2017. Revised 7 December 2017. Accepted 11 December 2017.
Funding: The study was supported by the Siberian Branch of Russian Academy of Sciences within the framework of the fundamental research package program.
Conflict of interest: Authors declare no conflict of interest.
Author contributions
Drafting the article: A.N. Kazantsev
Resources: A.R. Shabayev
Artistic design: N.N. Burkov
Critical revision of the article: A.I. Anufriyev, A.V. Mironov, V.Yu. Kheraskov
Surgical treatment: A.N. Kazantsev
Assistance in surgery: N.N. Burkov, A.R. Shabayev
Revascularization tactic selection: A.I. Anufriyev, A.V. Mironov, V.Yu. Kheraskov
Neurological examination: E.V. Ruban
Final approval of the version to be published: A.N. Kazantsev, N.N. Burkov, R.S. Tarasov, A.I. Anufriyev, A.R. Shabayev, E.V. Ruban, A.V. Mironov,
V.Yu. Kheraskov
References
- Шатравка А.В., Сокуренко Г.Ю., Суворов С.А., Ризаханова М.Р., Логинов И.А., Алексеева Н.В. Результаты операций каротидной эндартерэктомии, выполненных в остром периоде ишемического инсульта. Ангиология и сосудистая хирургия. 2016;22(2):133-137. Режим доступа: http://www.angiolsurgery.org/magazine/2016/2/18.htm [Shatravka A.V., Sokurenko G.Y., Suvorov S.A., Rizakhanova M.R., Loginov I.A., Alekseeva N.V. Outcomes of carotid endarterectomy performed in acute stage of ischaemic stroke. Angiol Sosud Khir. 2016;22(2):133-7. (In Russ.) PMID: 27336345. Available from: http://www.angiolsurgery.org/magazine/2016/2/18.htm]
- Цукурова Л.А., Тимченко Л.В., Головко Е.Н., Усачев А.А., Федорченко А.Н., Порханов В.А. Успешное проведение экстренных оперативных вмешательств на брахиоцефальных артериях у двух пациентов в острейшем периоде ишемического инсульта. Нейрохирургия. 2013;(4):70-72. Режим доступа: http://www.therjn.com/jour/article/view/65 [Cukurova L.A., Timchenko L.V., Golovko E.N., Usachev A.A., Fedorchenko A.P., Porkhanov V.A. The successful urgent operations on brachiocephalic arteries at two patients in acute period of ischemic stroke. Russian journal of neurosurgery. 2013;(4):70-72. (In Russ.) Available from: http://www.therjn.com/jour/article/view/65]
- Гудкова В.В., Шанина Т.В., Петрова Е.А., Стаховская Л.В. Транзиторная ишемическая атака мультидисциплинарная проблема. Неврология, нейропсихиатрия, психосоматика. 2012;4(3):20-24. http://dx.doi.org/10.14412/2074-2711-2012-397 [Gudkova V.V., Shanina T.V., Petrova E.A., Stakhovskaya L.V. Transient ischemic attack is a multidisciplinary problem. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(3):20-24. (In Russ.) http://dx.doi.org/10.14412/2074-2711-2012-397]
- Rathenborg L.K., Venermo M., Troëng T., Jensen L.P., Vikatmaa P., Wahlgren C., Ijäs P., Björck M., Kragsterman B. Editor's choice - Safety of carotid endarterectomy after intravenous thrombolysis for acute ischaemic stroke: a case-controlled multicentre registry study. Eur J Vasc Endovasc Surg. 2014;48(6):620-5. PMID: 25443523. http://dx.doi.org/10.1016/j.ejvs.2014.09.004
- Национальные рекомендации по ведению пациентов с заболеваниями брахиоцефальных артерий. Ангиология и сосудистая хирургия. 2013;19(S2):4-68. Режим доступа: http://www.angiolsurgery.org/recommendations/2013/recommendations_brachiocephalic.pdf [National guidelines on the management of patients with diseases of brachiocephalic arteries. Angiologiya i sosudistaya khirurgiya = Angiology and Vascular Surgery. 2013;19(S2):4-68. (In Russ.) Available from: http://www.angiolsurgery.org/recommendations/2013/recommendations_brachiocephalic.pdf]
- European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008;25(5):457-507. PMID: 18477843. http://dx.doi.org/10.1159/000131083
- Bazan H.A., Zea N., Jennings B., Smith T.A., Vidal G., Sternbergh W.C. 3rd. Urgent carotid intervention is safe after thrombolysis for minor to moderate acute ischemic stroke. J Vasc Surg. 2015;62(6):1529-38. http://dx.doi.org/10.1016/j.jvs.2015.07.082
- Gunka I., Krajickova D., Lesko M., Renc O., Raupach J., Jiska S., Lojik M., Chovanec V., Maly R. Safety of early carotid endarterectomy after intravenous thrombolysis in acute ischemic stroke. Ann Vasc Surg. 2017;44:353-360. PMID: 28479465. http://dx.doi.org/10.1016/j.avsg.2017.03.195
- Савелло А.В., Свистов Д.В., Сорокоумов В.А. Внутрисосудистые методы лечения ишемического инсульта: современное состояние и перспективы. Неврология, нейропсихиатрия, психосоматика. 2015;7(4):42-49. http://dx.doi.org/10.14412/2074-2711-2015-4-42-49 [Savello A.V., Svistov D.V., Sorokoumov V.A. Endovascular treatments for ischemic stroke: Present status and prospects. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(4):42-49. (In Russ.) http://dx.doi.org/10.14412/2074-2711-2015-4-42-49]
- Fassbender K., Dempfle C.E., Mielke O., Schwartz A., Daffertshofer M., Eschenfelder C., Dollman M., Hennerici M. Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator. Stroke. 1999;30:2101-2104. PMID: 10512913.
- Koraen-Smith L., Troeng T., Björck M., Kragsterman B., Wahlgren C.M. Urgent carotid surgery and stenting may be safe after systemic thrombolysis for stroke. Stroke. 2014;45(3):776-780. PMID: 24525950. http://dx.doi.org/10.1161/STROKEAHA.113.003763
- Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Borden W.B., Bravata D.M., Dai S., Ford E.S., Fox C.S., Franco S., Fullerton H.J., Gillespie C., Hailpern S.M., Heit J.A., Howard V.J., Huffman M.D., Kissela B.M., Kittner S.J., Lackland D.T., Lichtman J.H., Lisabeth L.D., Magid D., Marcus G.M., Marelli A., Matchar D.B., McGuire D.K., Mohler E.R., Moy C.S., Mussolino M.E., Nichol G., Paynter N.P., Schreiner P.J., Sorlie P.D., Stein J., Turan T.N., Virani S.S., Wong N.D., Woo D., Turner M.B.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics-2013 update. Circulation. 2013;127(1):143-152. PMID: 23283859. http://dx.doi.org/10.1161/CIR.0b013e318282ab8f
- Lambrinos A., Schaink A.K., Dhalla I., Krings T., Casaubon L.K., Sikich N., Lum C., Bharatha A., Pereira V.M., Stotts G., Saposnik G., Kelloway L., Xie X., Hill M.D. Mechanical thrombectomy in acute ischemic stroke: a systematic review. Can J Neurol Sci. 2016;43(4):455-60. PMID: 27071728, PMCID: PMC4926268. http://dx.doi.org/1010.1017/cjn.2016.30
- Romano D.G., Cioni S., Leonini S., Gennari P., Vallone I.M., Zandonella A., Puliti A., Tassi R., Casasco A., Martini G., Bracco S. Manual thromboaspiration technique as a first approach for endovascular stroke treatment: A single-center experience. Interv Neuroradiol. 2016;22(5):529-34. PMID: 27301390, PMCID: PMC5072211. http://dx.doi.org/10.1177/1591019916653256.
- Engelter S., Lyrer P. Antiplatelet therapy for preventing stroke and other vascular events after carotid endarterectomy. Cochrane Database Syst Rev. 2003;(3):CD001458. PMID: 12917908. http://dx.doi.org/10.1002/14651858.CD001458
- Capoccia L., Sbarigia E., Speziale F., Toni D., Fiorani P. Urgent carotid endarterectomy to prevent recurrence and improve neurologic outcome in mild-to-moderate acute neurologic events. J Vasc Surg. 2011;53(3):622-7;discussion 627-8. PMID: 21129904. http://dx.doi.org/10.1016/j.jvs.2010.09.016
- Михайлов М.С., Кириллов В.И., Ридель В.Ю., Алексеев А.Ю., Новожилов А.В., Эйдлин Е.Г., Зелёнкина Н.Ю., Соловов Д.В. Результаты реконструктивных операций на сонных артериях у больных в остром периоде ишемического инсульта. Ангиология и сосудистая хирургия. 2015;21(3):118-23. Режим доступа: http://www.angiolsurgery.org/magazine/2015/3/15.htm [Mikhailov M.S., Kirillov V.I., Ridel V.Y., Alekseev A.Y., Novozhilov A.V. Outcomes of reconstructive operations on carot+id arteries in acute period of ischaemic stroke. Angiol Sosud Khir. 2015;21(3):118-23. (In Russ.) PMID: 26355931. Available from: http://www.angiolsurgery.org/magazine/2015/3/15.htm]
- Tsivgoulis G., Krogias C., Georgiadis G.S., Mikulik R., Safouris A., Meves S.H., Voumvourakis K., Haršány M., Staffa R., Papageorgiou S.G., Katsanos A.H., Lazaris A., Mumme A., Lazarides M., Vasdekis S.N. Safety of early endarterectomy in patients with symptomatic carotid artery stenosis: an international multicenter study. Eur J Neurol. 2014;21(10):1251-7, e75-6. PMID: 24837913. http://dx.doi.org/10.1111/ene.12461
- Barbetta I., Carmo M., Mercandalli G., Lattuada P., Mazzaccaro D., Settembrini A.M. Outcomes of urgent carotid endarterectomy for stable and unstable acute neurologic deficits. J Vasc Surg. 2014;59(2):440-6. PMID: 24246539. http://dx.doi.org/10.1016/j.jvs.2013.08.035
- Naylor A.R. Delay may reduce procedural risk, but at what price to the patient? Eur J Vasc Endovasc Surg. 2008;35(4):383-391. PMID: 18261942. http://dx.doi.org/10.1016/j.ejvs.2008.01.002
- Guirgis M., Sieunarine K. Cerebral hyperperfusion syndrome: A rare postoperative complication of carotid endarterectomy. Am J Emerg Med. 2016;34(10):2054.e1-2054.e2. PMID: 27103082. http://dx.doi.org/10.1016/j.ajem.2016.03.010
- Казанцев А.Н. Персонифицированный выбор оптимальной стратегии хирургического лечения пациентов с сочетанным поражением коронарного русла и брахиоцефальных артерий. Сибирский медицинский журнал. 2017;1(32):74-78. Режим доступа: http://cardio-tomsk.ru/attachments/article/798/SMJ-2017-1-light.pdf [Kazantsev A.N. Personalized choice of the optimal strategy for surgical treatment of patients with combined lesions of the coronary bed and brachiocephalic arteries. Siberian Medical Journal. 2017;1(32):74-78. (In Russ.) Available from: http://cardio-tomsk.ru/attachments/article/798/SMJ-2017-1-light.pdf]