Vol. 21 No. 3 (2017)
ANESTHESIOLOGY & RESUSCITATION

Predictors of complications when transferring postoperative cardiac patients from the intensive care unit

K. Paromov
E. Volosevich City Hospital, Arkhangelsk, Russian Federation
Bio
M. Kirov
E. Volosevich City Hospital, Arkhangelsk, Russian Federation; Northern State Medical University, Arkhangelsk, Russian Federation

Published 2017-11-22

Keywords

  • postoperative period,
  • complications,
  • diastolic dysfunction

How to Cite

Paromov, K., & Kirov, M. (2017). Predictors of complications when transferring postoperative cardiac patients from the intensive care unit. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 21(3), 65–75. https://doi.org/10.21688/1681-3472-2017-3-65-75

Abstract

Aim. Emphasis in the study was placed on the evaluation of predictors of complications when transferring postoperative cardiac patients from the intensive care unit (ICU).
Methods. 60 patients after cardiac surgery were included into this prospective observational study, with 41 of them undergoing off-pump coronary artery bypass grafting (CABG). Before the transfer from ICU, echocardiographical criteria of their systolic and diastolic dysfunction, parameters of oxygenation, hemodynamic and metabolism status, as well as postoperative complications and duration of hospitalization were evaluated.
Results. Preoperatively, the patients had a moderate degree of heart failure and preserved ejection fraction. Those patients who had undergone valvular and combined procedures using cardiopulmonary bypass had higher Euroscore II values, more severe heart failure, prolonged duration of surgery, respiratory support and hospitalization in ICU and in hospital. The echocardiographical criteria of diastolic dysfunction before transfer from ICU were recorded in 14-77% patients. Despite a normal range of blood pressure, the systolic function of the left ventricle and preload (left atrial pressure), oxygenation and metabolic status, venous to arterial carbon dioxide difference (Pv-aCO2) and left ventricle performance index (Tei) exceeded the normal values before transfer from ICU. The correlation analysis revealed a relationship between duration of ICU and hospital stay and the criteria of heart failure severity (left atrial pressure [rho = 0.27, 95% CI 0.02–0.48, p = 0.04]) and left ventricle dysfunction (e’ [rho = 0.41, 95% CI 0.17–0.59, p<0.01]) before the transfer. The increase in fluid balance during ICU stay after off-pump coronary artery bypass surgery tended to result in a complicated postoperative period (AUC = 0.73, p = 0.02) and a higher risk of atrial fibrillation.
Conclusion. The impairment of the left ventricle diastolic function before transferring from ICU correlates with the duration of hospitalization. A positive fluid balance during ICU period after off-pump surgery might bring about postoperative complications and atrial fibrillation, thus predicting their onset.

Received 5 April 2017. Revised 10 August 2017. Accepted 15 August 2017.

Funding: The study did not have sponsorship.

Conflict of interest: The authors declare no conflict of interest.

Acknowledgement
The authors express their gratitude for patience and support during the study to the staff of Cardiac Surgery Department and Resuscitation Department.

References

  1. Никифоров С.Ф., Олофинская И.Е., Багиян Л.С. Исследование качества жизни у пожилых больных после операции на сердце. Качественная клиническая практика. 2003;(1):56-9. [Nikiforov S.F., Olofinskaya I.E., Bagian L.S. Evaluation quality of life after open heart operations in eldery. Kachestvennaya clinicheskaya praktika. 2003;(1):56-9. (In Russ.)]
  2. Litmathe J., Kurt M., Feindt P., Gams E., Boeken U. Predictors and outcome of ICU readmission after cardiac surgery. Thorac Cardiovasc Surg. 2009;57(7):391-4. PMID: 19795324. http://dx.doi.org/1055/s-0029-1185852
  3. Granton J., Cheng D. Risk stratification models for cardiac surgery. Semin Cardiothorac Vasc Anesth. 2008;12(3):167-74. PMID: 18805851. http://dx.doi.org/10.1177/1089253208323681
  4. Robin E., Futier E., Pires O., Fleyfel M., Tavernier B., Lebuffe G., Vallet B. Central venous-to-arterial CO2 difference as prognostic tool in high-risk surgical patients. Crit Care. 2015;19(1):227. PMID: 25967737. http://dx.doi.org/10.1186/s13054-015-0917-6
  5. Шевченко Ю.Л. Системный воспалительный ответ при экстремальной хирургической агрессии. М.: РАЕН, 2009. 276 с. [Shevchenko Yu.L. Systemic inflammatory response after extreme surgical aggression. Moscow, Russian Academy of Natural Science Publ.; 2009. 276 p. (In Russ.)].
  6. Heinze H., Paarmann H., Heringlake M., Groesdonk H.V. Measurement of central and mixed venous-to-arterial carbon dioxide differences in cardiac surgery patients. Cardiopulmonary pathophysiology. 2011;(15):29-37.
  7. Ponikowski P., Voors A.A., Anker S.D., Bueno H., Cleland J.G., Coats A.J., Falk V., Gonzalez-Juanatey J.R., Harjiola V.P., Jankowska E.A., Jessup M., Linde C., Nihoyannopoulos P., Parissis J.T., Pieske B., Riley J.P., Rosano G.M., Ruiloope L.M., Ruschitzka F., Rutten F.H., van der Meer P. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129-200. PMID: 27206819. http://dx.doi.org/10.1093/eurheartj/ehw128
  8. Lavine S.J., Al Balbissi K. Adverse cardiac events and the impared relaxation left ventricular filling pattern. J Am Soc Echocardiogr. 2016;29(7):699-708. http://dx.doi.org/10.1016/j.echo.2016.02.008
  9. Lakoumentas J.A., Panou F.K., Kotseroglou V.K., Aggeli K.I., Harbis P.K. The Tei index of myocardial performance: applications in cardiology. Helenic J Cardiol. 2005;46(1):52-8. PMID: 15807396.
  10. St John Sutton M., Wiegers S.E. The Tei index – a role in the diagnosis of heart failure? Eur Heart J. 2000;21(22):1822-4. PMID: 11052853. http://dx.doi.org/10.1053/euhj.2000.2391
  11. Marik P.E., Cavallazi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit Care Med. 2013;41(7):1774-81. PMID: 23774337. http://dx.doi.org/10.1097/CCM.0b013e31828a25fd
  12. Rhodes A., Evans L.E., Alhazzani W., Levy M.M., Antonelli M., Ferrer R., Kumar A., Sevransky J.E., Sprung C.L., Nunnally M.E., Rockwerg B., Rubenfeld G.D., Angus D.C., Annane D., Beale R.J., Bellinghan G.J., Bernard G.R., Chiche J.D., Coopersmith C., DeBacker D.P., French C.J., Fujishia S., Gerlach H., Hidalgo J.L., Hollenberg S.M., Jones A.E., Karnad D.R., Kleinpell R.M., Koh Y., Lisboa T.C., Machado F.R., Marini J.J., Marshall J.C., Mazuski J.E., Mclntyre L.A., McLean A.S., Mehta S., Moreno R.P., Myburgh J., Navalesi P., Nishida O., Osborn T.M., Perner A., Plunkett C.M., Ranieri M., Schorr C.A., Seckel M.A., Seymour C.W., Shieh L., Shukri K.A., Simpson S.Q., Singer M., Thompson B.T., Townsend S.R., Van der Poll T., Vincent J.L., Weirsinga W.J., Zimmerman J.L., Dellinder R.P. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43(3):304-77. PMID: 28101605. http://dx.doi.org/10.1007/s00134-017-4683-6
  13. Nagueh S.F., Middleton K.J., Kopelen H.A., Zoghbi W.A., Quinones M.A. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997;30(6):1527-33. PMID: 9362412.
  14. Garcia M.J., Ares M.A., Asher C., Rodriques L., Vandervoort P., Thomas J.D. An index of early ventricular filling that combined with pulsed Doppler peak E velocity may estimate capillary wedge pressure. J Am Coll Cardiol. 1997;29(2):448-54. PMID: 9015003.
  15. Кузьков В.В., Киров М.Ю. Паромов К.В., Ленькин А.И. Целенаправленная оптимизация гемодинамики в периоперационном периоде: возможности и перспективы. Патология кровообращения и кардиохирургия. 2014;18(3):59-66. http://dx.doi.org/10.21688/1681-3472-2014-3-59-66 [Kuzkov V.V., Kirov M.Yu., Paromov K.V., Lenkin A.I. Goal-oriented optimization of hemodynamics during perioperative period: opportunities and future perspectives. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2014;18(3):59-66. (In Russ.). http://dx.doi.org/10.21688/1681-3472-2014-3-59-66]
  16. Concha M.R., Mertz V.F., Cortines L.I., Gonzales K.A., Butte J.M. Pulse contour analysis and transesophageal echocardiography: a comparison of measurements of cardiac output during laparoscopic colon surgery. Anesth Analg. 2009;109(1):114-8. PMID: 19535700. http://dx.doi.org/10.1213/ane.0b013e3181a491b8.
  17. Rosendal C., Almamat Uulu K., DeSimone R., Wolf I., Deckert A., Martin E.O., Bottinger B.W., Rauch H. Right ventricular function during orthopic liver transplantation: three-dimentional transesophageal echocardiography and thermodilution. Ann Transplant. 2012;17(1):21-30. PMID: 22466905.
  18. Maeder M.T., Karapanagiotidis S., Dewar E.M., Kaye D.M. Accuracy of echocardiographic cardiac index assessment in subjects with preserved left ventricular ejection fraction. Echocardiography. 2015;32(11):1628-38. PMID: 25728504. http://dx.doi.org/10/1111/echo.12928
  19. Soslow J.H., Xu M., Slaughter J.C., Stanley M., Crum K., Markham L.W., Parra D.A. Evaluation of echocardiographic measures of left ventricular function in patients with Duchenne muscular dystrophy: assessment of reproducibility and comparison to cardiac magnetic resonance imaging. J Am Soc Echocardiogr. 2016;29(10):983-91. PMID: 27544870. http://dx.doi.org/10.1016/j.echo.2016.07.001
  20. Nagueh S.F., Smiseth O.A., Appleton C.P., Byrd B.F. 3rd, Dokainish H., Edvardsen T., Flachskampf F.A., Gillebert T.C., Klein A.L., Lancelotti P., Marino P., Oh JK., Popescu B.A., Waqqoner A.D. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and European association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging. 2016;17(12):1321-60. https://doi.org/10.1093/ehjci/jew082
  21. Чернявский А.М., Ефремова О.С., Рузматов Т.М., Эфендиев В.У. Предикторы отдаленной летальности больных ишемической болезнью сердца с выраженной левожелудочковой дисфункцией. Патология кровообращения и кардиохирургия. 2015;19(2):49-54. [Cherniavsky A.M., Yefremova O.S., Ruzmatov T.M., Efendiyev V.U. Predictors of remote mortality of CHD patients with severe left ventricular dysfunction. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2015;19(2):49-54. (In Russ.). http://dx.doi.org/10.21688/1681-3472-2015-2-49-54]
  22. Turan T., Agac M.T., Aykan A.C., Kul S., Akyuz A.R., Gokdeniz T., Gul L., Cenqiz E., Boyaci F. Erkan H., Akdemir R., Celic S. Usefulness of heart-type fatty acid-binding protein and myocardial performance index for early detection of 5-fluorouracil cardiotoxicity. Angiology. 2017;68(1):52-8. PMID: 26980771. http://dx.doi.org/10.1177/0003319716637516
  23. Goroshi M., Chand D. Myocardial performance index (Tei index): a simple tool to identify cardiac dysfunction in patients with diabetes mellitus. Indian Heart J. 2016;68(1):83-7. PMID: 26896273. http://dx.doi.org/10.1016/j.ihj.2015.06.022
  24. Moorandian S.J., Goldberg C.S., Crowley D.С., Ludomirsky A. Evaluation of a noninvasive index of global ventricular function to predict rejection after pediatric cardiac transplantation. Am J Cardiol. 2000;86(3):358-60. PMID: 10922454.
  25. Uzunhasan I, Bader K., Okcun B., Hatemi A.C., Mutlu H. Correlation of the Tei index with left ventricular dilatation and mortality in patients with acute myocardial infarction. Int Heart J. 2006;47(3):331-42. PMID: 16823239.