Published 2016-08-17
Keywords
- postinfarction ventricular septal defect,
- occluder,
- endovascular treatment,
- myocardial infarction.
How to Cite
Copyright (c) 2016 Khelimskiy D.A., Krestyaninov O.V., Osiev A.G., Shermuk A.A., Grankin D.S., Kretov E.I., Ibragimov R.Y., Baystrukov V.I., Kim E.M., Marchenko A.V., Zubarev D.D., Redkin D.A., Naryshkin I.A., Naydenov R.A., Pokushalov E.A., Karaskov A.M.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Aim: The study was designed to evaluate the possibility and safety of transcatheter closure of postinfarction ventricular septal defects in different periods after acute myocardial infarction.
Methods: Over a period from 2010 to 2015 15 patients (11 females and 4 males) underwent transcatheter closure of postinfarction ventricular septal defects. The time from the onset of infarction to the intervention varied between 1 day and 6 months (mean 10.9 weeks). Three patients were treated in an acute phase of infarction (two weeks or less). The defect size ranged 7-24 mm (mean 13.5 mm), while the implanted devices sized 12-34 mm (mean 22.8 mm). The procedure and screening time amounted to 67-170 (mean 115.3) and 14-78 (mean 32.5) minutes respectively.
Results: A successful device implantation occurred in all but one patient whose occluder was dislodged. This patient later underwent successful surgical VSD closure. Occluder implantation failed to improve the clinical status of two patients in a critical condition. They developed multiple organ failure and died at 2 and 9 days after the procedure.
Conclusion: Transcatheter closure of postinfarction ventricular septal defects may be an alternative to surgery in patients with suitable anatomy and multiple comorbidities. However, in-hospital mortality remains high, even after successful occluder implantation.
References
- Pohjola-Sintonen S, Muller JE, Stone PH, Willich SN, Antman EM, Davis VG, Parker CB, Braunwald E. Ventricular septal and free wall rupture complicating acute myocardial infarction: experience in the Multicenter Investigation of Limitation of Infarct Size. Am Heart J. 1989;117:809-18.
- Crenshaw BS, Granger CB, Birnbaum Y, Pieper KS, Morris DC, Kleiman NS, Vahanian A, Califf RM, Topol EJ. Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators. Circulation. 2000;101:27-32.
- Yip HK, Fang CY, Tsai KH, Chang HW, Yeh KH, Fu M, Wu CJ. The potential impact of primary percutaneous coronary intervention on ventricularseptal rupture complicating acute myocardial infarction. Chest. 2004;125:1622-8.
- Bhimji SH. Ventricular septal rupture following myocardial infarction. Available at: http://emedicine.medscape.com/article/428240 (accessed 02.04.16).
- Park JY, Park SH, Oh JY, Kim IJ, Lee YH, Park SH, Kwon KH. Delayed ventricular septal rupture after percutaneous coronary intervention in acute myocardial infarction. Korean J Intern Med. 2005;20:243-6.
- Poulsen SH, Praestholm M, Munk K, Wierup P, Egeblad H, Nielsen-Kudsk JE. Ventricular septal rupture complicating acute myocardial infarction: clinical characteristics and contemporary outcome. Ann Thorac Surg. 2008;85:1591-6.
- Harikrishnan S, Tharakan J, Titus T, Kumar A, Sivasankaran S, Krishnamoorthy KM. Ventricular septal rupture following myocardial infarction: clinical, haemodynamic, angiographic profile and long-term outcome. Int J Cardiol. 2007;120:279-80.
- Assenza GE, Valente AM, Volpe M, Martucci G, Landzberg MJ, Lock JE. Transcatheter closure of post-myocardial infarction ventricular septal rupture. Circ Cardiovasc Interv. 2013;6:59-67. http://dx.doi.org/10.1161/CIRCINTERVENTIONS.112.972711
- Edwards BS, Edwards WD, Edwards JE. Ventricular septal rupture complicating acute myocardial infarction: identification of simple and complex types in 53 autopsied hearts. Am J Cardiol. 1984;54:1201.
- Menon V, Webb JG, Hillis LD, Sleeper LA, Abboud R, Dzavik V, Slater JN, Forman R, Monrad ES, Talley JD, Hochman J.S. Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry. Should we emergently revascularize Occluded Coronaries in cardiogenic shock? J Am Coll Cardiol. 2000;36:1110-6.
- Sugiki H, Murashita T, Kunihara T, Matsuzaki K, Shiiya N, Yasuda K. Risk factors for the surgical repair of ventricular septal perforation; an 8-year multi institutional analysis. KyobuGeka. 2005;58:278-83.
- Arora R, Trehan V, Kumar A, Madhuri K. Transcatheter closure of congenital ventricular septal defects: experience with various devices. J Interv Cardiol. 2003;16:83-91.
- Michel-Behnke I, Waldecker B, Akintuerk H, Valeske K, Schranz D. Percutaneous closure of congenital and acquired ventricular septal defects—considerations on selection of the occlusion device. J Interv Cardiol. 2005;18:89-99.
- Lee EM, Roberts DH, Walsh KP. Transcatheter closure of a residual postmyocardial infarction ventricular septal defect with the amplatzer septal occluder. Heart. 1998; 80(5):522-4.
- Barker TA, Ramnarine IR, Woo EB, Grayson AD, Fabri BM, Bridgewater B, Grotte GJ. Repair of post-infarct ventricular septal defect with or without coronary artery bypass grafting in the northwest of England: a 5-year multi-institutional experience. Eur J Cardiothorac Surg. 2003;24(6):940-6. http://dx.doi.org/10.1016/S1010-7940(03)00465-2
- Jeppsson A, Liden H, Johnsson P, Hartford M, Radegran K. Surgical repair of post infarction ventricular septal defects: a national experience. Eur J Cardiothorac Surg. 2005;27(2):216-21.
- Deja MA, Szostek J, Widenka K, Szafron B, Spyt TJ, Hickey MJ, Sosnowski AW. Post infarction ventricular septal defect - can we do better? Eur J Cardiothorac Surg. 2000;18:194-201.
- Thiele H, Kaulfersch C, Daehnert I, Schoenauer M, Eitel I, Borger M, Schuler G. Immediate primary transcatheter closure of postin-farction ventricular septal defects. Eur Heart J. 2009;30:81-8. http://dx.doi.org/10.1093/eurheartj/ehn524
- Papalexopoulou N, Young CP, Attia RQ. What is the best timing of surgery in patients with post-infarct ventricular septal rupture? Interact Cardiovasc Thorac Surg. 2013;16(2):193-6. http://dx.doi.org/10.1093/icvts/ivs444
- Lukin OP, Andrievskikh SI, Piskunov SA, Derksen SA. Case report of combined correction of postinfarction ventricular septal defect. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2013;1:87-9. (In Russ.).
- David TE. Operative management of postinfarction ventricular septal defect. Semin Thorac Cardiovasc Surg. 1995;7:208-13.
- Scanlon PJ, Montoya A, Johnson SA, McKeever LS, Sullivan HJ, Bakhos M, Pifarre R. Urgent surgery for ventricular septal rupture complicating acute myocardial infarction. Circulation. 1985;72(suppl II):II-185-90.
- Maltais S, Ibrahim R, Basmadjian A, Carrier M, Bouchard D, Cartier R, Demers P, Ladouceur M, Pellerin M, Perrault LP. Postinfarction ventricular septal defects: towards a new treatment algorithm? Ann Thorac Surg. 2009;87:687-692. http://dx.doi.org/10.1016/j.athoracsur.2008.11.052
- Arnaoutakis GJ, Zhao Y, Timothy JG, Sciortino CM, McCarthy PM, Conte JV. Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the society of thoracic surgeons national database. Ann Thorac Surg. 2012;94:436. http://dx.doi.org/10.1016/j.athoracsur.2012.04.020