Vol. 20 No. 3 (2016)
CORONARY ARTERY DISEASES

In-hospital results of rheolytic catheter thrombectomy in patients with STEMI

M Malkhasyan
Regional Clinical Hospital of Khanty-Mansiysk, Khanty-Mansiysk 628011, Russian Federation
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V Kuznetsov
Tyumen Cardiology Center, Branch of Research Institute of Cardiology, Tyumen 625026, Russian Federation
Bio
I Bessonov
Tyumen Cardiology Center, Branch of Research Institute of Cardiology, Tyumen 625026, Russian Federation
Bio
P Pavlov
Regional Clinical Hospital of Khanty-Mansiysk, Khanty-Mansiysk 628011, Russian Federation
Bio

Published 2016-11-10

Keywords

  • myocardial infarction,
  • rheolytic catheter thrombectomy,
  • AngioJet,
  • percutaneous coronary intervention

How to Cite

Malkhasyan, M., Kuznetsov, V., Bessonov, I., & Pavlov, P. (2016). In-hospital results of rheolytic catheter thrombectomy in patients with STEMI. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 20(3), 54–61. https://doi.org/10.21688/1681-3472-2016-3-54-61

Abstract

Aim. The article focuses on the evaluation of short-term efficacy of rheolytic thrombectomy (AngioJet) in patients with STEMI.
Methods. 188 patients (85.6% men) with STEMI underwent primary PCI by means of rheolytic catheter thrombectomy (AngioJet). The mean age was 54.1 ± 10.7 years. 32 (17 %) of patients had old myocardial infarction. 104 (55.9 %) patients were diagnosed with ST-elevated inferior myocardial infarction. 22 (12 %) patients were operated under cardiogenic shock. Mean time from the appearance of symptoms to admission was 222.5 [70, 584] min. Anterior interventricular artery (38.3 %) and right coronary artery (43.6 %) were the main infarction-related arteries.
Results. Complete thrombotic occlusion of the coronary artery occurred in 144 (77.4%) patients. Mean “door-to-balloon” time amounted to 41.5 [30; 60]. Coronary thrombus was fully removed in 107 (60.8%) of patients. Stents with antiproliferative effect were implanted in 48.8 % of patients. Immediate angiographic success was achieved in 177 (94.1%) cases. Mean time of PCI was 60 [50; 80] min. PCI complications were registered in 3 (1.6%) patients. Intraoperative life-threatening arrhythmias happened in 22 (11.7 %) patients. The phenomenon of "no-reflow" occurred in 6 (3.2%) PCI cases. The rate of in-hospital mortality was 5.9%, including patients with cardiogenic shock (36.4%) and those without it (1.9 %). MACCE (main adverse cardio-cerebral events) were observed in 15 (8%) cases. According to ECG data obtained postoperatively, 26 % of patients demonstrated no regional asynergy, while a decrease in myocardial contractile function occurred in just 26 % of cases, with the average left ventricular ejection fraction running to 57.5±9 %. Mean in-hospital stay was 9.5±0.6 days.
Conclusion. The results of this study suggest that rheolytic catheter thrombectomy (AngioJet) is a safe and effective modality. Immediate hospital results show low rate complications and low in-hospital mortality.

Received 13 April 2016. Accepted 9 June 2016.

Conflict of interest: The authors declare no conflict interests.

References

  1. Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS. Population Trends in the Incidence and Outcomes of Acute Myocardial Infarction. N Engl J Med. 2010;362(23):2155-65. DOI: 10.1056/NEJMoa0908610
  2. Levine GN, O’Gara PT, Bates ER et al. 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. J Am Coll Cardiol. 2016;67(10):1235-50. DOI: 10.1016/j.jacc.2015.10.005
  3. Kuznetsov VA, Yaroslavskaya EI, Pushkarev GS, Zyryanov IP, Bessonov IS, Gorbatenko EA, Nyamtsu AM. Interrelation of transcutaneous coronary interventions for acute forms of coronary heart disease and mortality parameters in tyumen region inhabitants. Russian Journal of Cardiology. 2014;(6):42-46. DOI:10.15829/1560-4071-2014-6-42-46
  4. Fröbert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T, Maeng M, Aasa M, Angerås O, Calais F, Danielewicz M, Erlinge D, Hellsten L, Jensen U, Johansson AC, Kåregren A, Nilsson J, Robertson L, Sandhall L, Sjögren I, Ostlund O, Harnek J, James SK; TASTE Trial. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med. 2013;369(17):1587-97. DOI: 10.1056/NEJMoa1308789
  5. Vandermolen S, Marciniak M, Byrne J, De Silva K. Thrombus aspiration in acute myocardial infarction: concepts, clinical trials, and current guidelines? Coron Artery Dis. 2016;27(3):233-43. DOI: 10.1097/MCA.0000000000000335
  6. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg PG, James SK, Atar D. et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33(20):2569-619. DOI: 10.1093/eurheartj/ehs215
  7. Ganz W. The thrombolysis in myocardial infarction (TIMI) trial. N Engl J Med. 1985;313(16):1018. DOI: 10.1056/NEJM198510173131611
  8. Gibson CM, Cannon CP, Murphy SA, Marble SJ, Barron HV, Braunwald E. Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction. Circulation. 2002;105(16):1909-13. PMID: 11997276
  9. Deng SB, Wang J, Xiao J, Wu L, Jing XD, Yan YL, Du JL, Liu YJ, She Q. Adjunctive manual thrombus aspiration during ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. PLoS One. 2014;9(11):e113481. DOI: 10.1371/journal.pone.0113481
  10. De Luca G, Navarese EP, Suryapranata H. A meta-analytic overview of thrombectomy during primary angioplasty. Int J Cardiol. 2013;166(3):606-12. DOI: 10.1016/j.ijcard.2011.11.102
  11. Jolly SS, Niemela K. Aspiration thrombectomy in ST-elevation myocardial infarction. EuroIntervention. 2014;10 Suppl T:T35-8. DOI: 10.4244/EIJV10STA7
  12. Calais F, Lagerqvist B, Leppert J, James SK, Fröbert O. Thrombus aspiration in patients with large anterior myocardial infarction. Am Heart J. 2016;172:129-34. DOI: 10.1016/j.ahj.2015.11.012
  13. Berry C, Lee M, Ahmed N. Thrombus aspiration during myocardial infarction. N Engl J Med. 2014;370(7):674. DOI: 10.1056/NEJMc1315678#SA1
  14. Loubeyre C, Morice MC, Lefèvre T, Piéchaud JF, Louvard Y, Dumas P. A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol. 2002;39(1):15-21. PMID: 11755281
  15. Möckel M, Vollert J, Lansky AJ, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Kornowski R, Dudek D, Farkouh ME, Parise H, Mehran R, Stone GW; Horizons-AMI Trial Investigators. Comparison of direct stenting with conventional stent implantation in acute myocardial infarction. Am J Cardiol. 2011;108(12):1697-703. DOI: 10.1016/j.amjcard.2011.07.040
  16. Ali A, Cox D, Dib N, Brodie B, Berman D, Gupta N, Browne K, Iwaoka R, Azrin M, Stapleton D, Setum C, Popma J; AIMI Investigators. Rheolytic thrombectomy with percutaneous coronary intervention for infarct size reduction in acute myocardial infarction: 30-day results from a multicenter randomized study. J Am Coll Cardiol. 2006;48(2):244-52. DOI: 10.1016/j.jacc.2006.03.044
  17. Migliorini A, Stabile A, Rodriguez AE, Gandolfo C, Rodriguez Granillo AM, Valenti R, Parodi G, Neumann FJ, Colombo A, Antoniucci D. Comparison of AngioJet Rheolytic Thrombectomy Before Direct Infarct Artery Stenting With Direct Stenting Alone in Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2010;56(16):1298-1306. DOI: 10.1016/j.jacc.2010.06.011
  18. Puymirat E, Simon T, Steg PG, Schiele F, Guéret P, Blanchard D, Khalife K, Goldstein P, Cattan S, Vaur L, Cambou JP, Ferrières J, Danchin N; USIK USIC 2000 Investigators; FAST MI Investigators. Association of changes in clinical characteristics and management with improvement in survival among patients with ST-elevation myocardial infarction. JAMA. 2012;308(10):998-1006. DOI: 10.1001/2012.jama.11348
  19. Thiele H, Ohman EM, Desch S, Eitel I, de Waha S. Management of cardiogenic shock. Eur Heart J. 2015;36(20):1223-30. DOI: 10.1093/eurheartj/ehv051
  20. Stone GW, Witzenbichler B, Godlewski J, Dambrink JHE, Ochala A, Chowdhary S, El-Omar M, Neunteufl T, Metzger DC, Dizon JM, Wolff SD, Brener SJ, Mehran R, Maehara A, Gibson CM. Intralesional abciximab and thrombus aspiration in patients with large anterior myocardial infarction: one-year results from the INFUSE-AMI trial. Circ Cardiovasc Interv. 2013;6(5):527-34. DOI: 10.1161/CIRCINTERVENTIONS.113.000644