Vol. 19 No. 3 (2015)
CONGENITAL HEART DISEASES

Mechanical function of the right ventricle in infants with tetralogy of Fallot

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  • S. Sukhanov,
  • E. Orekhova,
  • U. Sinelnikov,
  • M. Sukhanov
S. Sukhanov
Federal Center for Cardiovascular Surgery Ministry of Health Care of Russian Federation, 35 Marshal Zhukov St., 614000 Perm, Russian Federation
Bio
E. Orekhova
Federal Center for Cardiovascular Surgery Ministry of Health Care of Russian Federation, 35 Marshal Zhukov St., 614000 Perm, Russian Federation
Bio
U. Sinelnikov
Federal Center for Cardiovascular Surgery Ministry of Health Care of Russian Federation, 35 Marshal Zhukov St., 614000 Perm, Russian Federation
Bio
M. Sukhanov
Federal Center for Cardiovascular Surgery Ministry of Health Care of Russian Federation, 35 Marshal Zhukov St., 614000 Perm, Russian Federation
Bio
DOI: https://doi.org/10.21688/1681-3472-2015-3-19-25

Published 2015-10-22

Keywords

  • tetralogy of Fallot,
  • right ventricle,
  • longitudinal strain,
  • strain rate

How to Cite

Sukhanov, S., Orekhova, E., Sinelnikov, U., & Sukhanov, M. (2015). Mechanical function of the right ventricle in infants with tetralogy of Fallot. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 19(3), 19–25. https://doi.org/10.21688/1681-3472-2015-3-19-25

Copyright (c) 2015 Sukhanov S.G., Orekhova E.N., Sinelnikov U.S., Sukhanov M.S.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective. The function of the right ventricle (RV) in patients with tetralogy of Fallot (ToF) largely determines the immediate and long-term results of surgical correction of the defect. The aim of this study was to evaluate the mechanical function of RV by analyzing the endocardium movement velocity in infants with ToF.
Methods. The study involved 25 ToF patients 3.9±3 months old and 20 healthy children as the comparison group. The vector analysis used allowed for evaluating longitudinal strain (S) and strain rate (SR) of the right ventricle.
Results. RV S was lower in ToF patients as compared to healthy ones (-11.7±4.1 against -32.1±3.9%, р <0.05). SR was also significantly reduced in patients with ToF as compared to the healthy ones (-1.4±0.6% against -3.0±0.6%, p<0.05). In patients with ToF RV S was smaller than LV S (-11.7±4.1% against -15±5%, p<0.05). Also reduced was RV SR in patients with ToF both in early diastole (1.5±0.54 vs. 3.2±0.53 s-1, p<0.05), and in late diastole (0.5±0.5 vs. 1.6±0.5 s-1, p<0.05).
It was found out that the pulmonic valve gradients correlate with RV S (Rs = 0.89 and 0.8), while inverse correlation was observed between systolic SR and the pulmonary artery trunk and branches. Mechanical remodeling of RV in patients with ToF manifests itself by a decrease in global and regional systolic and diastolic strain.
Conclusion. Systolic mechanical remodeling of RV in ToF patients makes itself evident by a considerable decrease in the velocity of RV global longitudinal systolic deformation in proportion to the degree of obstruction of the outflow tract of the right ventricle. Diastolic mechanical remodeling manifests itself by pronounced impaired relaxation in the form of RV monophasic filling in the early and late diastoles.

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