Vol. 16 No. 3 (2012)
CARDIOLOGY

Cytokine profile in chronic heart failure

PDF (Русский)
  • Ye. Berezikova,
  • M. Pustovetova,
  • S. Shilov,
  • A. Yefremov,
  • I. Safronov,
  • Ye. Samsonova,
  • A. Teplyakov,
  • Yu. Torim
Ye. Berezikova
Novosibirsk State Medical University
Bio
M. Pustovetova
Novosibirsk State Medical University
Bio
S. Shilov
Novosibirsk State Medical University
Bio
A. Yefremov
Novosibirsk State Medical University
Bio
I. Safronov
Novosibirsk State Medical University
Bio
Ye. Samsonova
Novosibirsk State Medical University
Bio
A. Teplyakov
Research Institute of Cardiology SB RAMS, Tomsk
Bio
Yu. Torim
Research Institute of Cardiology SB RAMS, Tomsk
Bio
DOI: https://doi.org/10.21688/1681-3472-2012-3-57-60

Published 2012-09-25

Keywords

  • CHRONIC HEART FAILURE,
  • INTERLEUKIN-1β,
  • RECEPTOR ANTAGONIST OF INTERLEUKIN-1

How to Cite

Berezikova, Y., Pustovetova, M., Shilov, S., Yefremov, A., Safronov, I., Samsonova, Y., Teplyakov, A., & Torim, Y. (2012). Cytokine profile in chronic heart failure. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 16(3), 57–60. https://doi.org/10.21688/1681-3472-2012-3-57-60

Copyright (c) 2012 Berezikova Ye.N., Pustovetova M.G., Shilov S.N., Yefremov A.V., Safronov I.D., Samsonova Ye.N., Teplyakov A.T., Torim Yu.Yu.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The relationship of cytokines, interleukin-1β and receptor antagonist of interleukin-1, and the severity and nature of chronic heart failure in patients with coronary heart disease was evaluated. We examined 94 patients with CHF. In patients with a favorable clinical course, IL-1 levels significantly decreased by the end of the observation, whereas in patients with an unfavorable course, in contrast, they tended to increase. It is established that a decline in IL-1Ra occurs with increasing severity of heart failure and is accompanied by increased levels of proinflammatory cytokines IL-1β. The levels of cytokines IL-1β and IL-1 Ra in the serum are interrelated with the severity and course of CHF. Determination of the levels of IL-1β and IL-1Ra in the serum can be recommended for early prediction of severity and nature of CHF.

PDF (Русский)

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