Vol. 29 No. 4 (2025): Patologiya krovoobrashcheniya i kardiokhirurgiya
ORIGINAL ARTICLES

Subclinical right ventricular systolic dysfunction and left ventricular myocardial performance in patients with severe aortic stenosis: а prospective single-center non-randomized study

pdf (Русский)
  • Elena N. Pavlyukova,
  • Veronica G. Timoshenko,
  • Ravil M. Sharifulin,
  • Alexander V. Afanasyev,
  • Sergey I. Zheleznev,
  • Sofya V. Semyahina,
  • Alexander V. Bogachev-Prokophiev
Elena N. Pavlyukova
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russian Federation
Bio
Veronica G. Timoshenko
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Ravil M. Sharifulin
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Alexander V. Afanasyev
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Sergey I. Zheleznev
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Sofya V. Semyahina
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Alexander V. Bogachev-Prokophiev
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
DOI: https://doi.org/10.21688/1681-3472-2025-4-78-88

Published 2026-01-21

Keywords

  • aortic stenosis; echocardiography; left ventricular myocardial work; right ventricular strain; right ventricular systolic dysfunction

How to Cite

Pavlyukova, E. N. ., Timoshenko, T., Sharifulin, R. M. ., Afanasyev, A. V. ., Zheleznev, S. I. ., Semyahina, S. V. ., & Bogachev-Prokophiev, A. V. . (2026). Subclinical right ventricular systolic dysfunction and left ventricular myocardial performance in patients with severe aortic stenosis: а prospective single-center non-randomized study. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 29(4), 78–88. https://doi.org/10.21688/1681-3472-2025-4-78-88

Copyright (c) 2026 Елена Николаевна Павлюкова, Вероника Георгиевна Тимошенко, Равиль Махарамович Шарифулин, Александр Владимрович Афанасьев, Серегй Иванович Железнев, Софья Владиславовна Семяхина, Александр Владимрович Богачев-Прокофьев

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: The number of patients with aortic stenosis (AS) is increasing with the aging population. According to current guidelines, surgical treatment is recommended for severe AS in patients with symptoms of heart failure, a reduced ejection fraction (EF), and global left ventricular (LV) Strain. LVEF does not always reflect its contractility. Assessing right ventricular (RV) function is also important, as its dysfunction may persist even after aortic valve surgery.

Objective: The study was aimed to assess RV global strain, strain of RV free wall and LV myocardial performance in patients with severe AS.

Methods: This prospective non-randomized study included 72 patients with degenerative aortic valve disease and an effective orifice area of less than 1.0 cm2. The complex of examination methods included echocardiography and Speckle Tracking Imaging-2D Strain technology for assessing LV and RV deformation, LV myocardial function, 3D visualization of RV with subsequent construction of a 3D RV model and calculation of EF, fractional area change, linear dimensions, and tricuspid annulus displacement amplitude.

Results: Decreased LV myocardial function was detected in 24 patients (33.3 %). Subclinical RV systolic dysfunction, namely decreased RV global strain, was detected in 40 (55.6 %) patients, while decreased RV free wall strain was observed in 11 (15.3 %) patients. Interplay was revealed between subclinical RV systolic dysfunction and LV myocardial performance in patients with severe AS.

Conclusion: Subclinical LV and RV dysfunctions are observed in a significant number of patients with severe AS. Analysis and use of these data will enable to change the approach to the AS classification and the timing of surgical treatment in the future.

Conclusion: Subclinical left and right ventricular dysfunction is observed in a significant number of patients with severe aortic stenosis based on echocardiography. Analysis and use of these data will likely lead to changes in the classification of AS and the timing of surgical treatment.

Keywords: aortic stenosis, echocardiography, right ventricular systolic dysfunction, left ventricular myocardial function, right ventricular deformation.

pdf (Русский)

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