Vol. 28 No. 4 (2024)
REVIEWS

Aspiration thrombectomy for the treatment of acute myocardial infarction in the light of critical analysis of contemporary trials: a review

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  • E.S. Gergert,
  • S.E. Pekarskiy,
  • A.E. Baev,
  • M.G. Tarasov,
  • I.V. Suslov,
  • A.A. Gorokhovsky,
  • S.M. Sultanov,
  • Yu.I. Bogdanov
E.S. Gergert
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
S.E. Pekarskiy
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
A.E. Baev
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
M.G. Tarasov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
I.V. Suslov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Bio
A.A. Gorokhovsky
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
S.M. Sultanov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Yu.I. Bogdanov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Identification of studies via databases
DOI: https://doi.org/10.21688/1681-3472-2024-4-18-32

Published 2024-12-27

Keywords

  • Acute Coronary Syndrome,
  • Myocardial Infarction,
  • Percutaneous Coronary Intervention,
  • PubMed,
  • ST Elevation Myocardial Infarction,
  • Thrombectomy,
  • Thrombosis
    • ...More
    Less

How to Cite

Gergert, E., Pekarskiy, S., Baev, . A., Tarasov, M., Suslov, I., Gorokhovsky, . A., Sultanov, S., & Bogdanov, Y. (2024). Aspiration thrombectomy for the treatment of acute myocardial infarction in the light of critical analysis of contemporary trials: a review. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 28(4), 18–32. https://doi.org/10.21688/1681-3472-2024-4-18-32

Copyright (c) 2024 Gergert E.S., Pekarskiy S.E., Baev A.E., Tarasov M.G., Suslov I.V., Gorokhovsky A.A., Sultanov S.M., Bogdanov Yu.I.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: The study was aimed at assessing the available data on the efficacy and safety of thromboaspiration in acute coronary syndrome and its prospects for more frequent using in routine clinical practice.
Methods: A search was performed in the Medline (PubMed), Cochrane Library and Web of Science databases for the period from 2000 to 2024 using the following keywords: “thrombectomy”, “thrombus aspiration”, “thromboaspiration” and “myocardial infarction”. Randomized controlled trials, prospective cohort and registry studies, and meta-analyses were included in the study, while experimental studies and studies with small samples (less than 50 patients) were excluded. The criteria for the efficacy of thromboaspiration itself were critically analyzed, as well as the impact of the device and its design on the efficacy and safety of thromboaspiration were assessed.
Results: Of the 230 search results, 45 original publications that met the selection criteria were included in the review. Most studies assessing the efficacy/safety of therapy did not take into account the fact that 20-30% of thromboaspiration from coronary arteries were technically unsuccessful that is quite enough to underestimate its efficacy.
Conclusion: The probable reason for the inconsistent results of thromboaspiration trials is high proportion of cases of technically unsuccessful outcomes related to the failure of extracting thrombotic contents from the aspiration catheter. Thromboaspiration is an etiological method for treating acute coronary artery thrombosis, and optimization of the design of thromboaspiration catheters and surgical techniques can significantly improve its efficacy and fully reveal the potential of this method for treating myocardial infarction.

Received 25 September 2024. Revised 29 November 2024. Accepted 2 December 2024.

Funding
The study did not have sponsorship.

Conflict of interest
The authors declare no conflict of interest.

Contribution of the authors
Conception and study design: E.S. Gergert, S.E. Pekarskiy,
A.E. Baev, M.G. Tarasov, I.V. Suslov, A.A. Gorokhovsky, S.M. Sultanov, Yu.I. Bogdanov
Data collection and analysis: E.S. Gergert, S.E. Pekarskiy,
I.V. Suslov, A.A. Gorokhovsky
Drafting the article: E.S. Gergert, I.V. Suslov, A.A. Gorokhovsky
Critical revision of the article: E.S. Gergert, S.E. Pekarskiy, A.E. Baev, M.G. Tarasov, I.V. Suslov, A.A. Gorokhovsky, S.M. Sultanov, Yu.I. Bogdanov
Final approval of the version to be published: E.S. Gergert, S.E. Pekarskiy, A.E. Baev, M.G. Tarasov, I.V. Suslov, A.A. Gorokhovsky, S.M. Sultanov, Yu.I. Bogdanov

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