Vol. 27 No. 4 (2023)
REVIEWS

Modulation of the autonomic nervous system for preventing perioperative atrial fibrillation: a review of literature

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  • V.V. Shabanov,
  • V.V. Beloborodov,
  • T.U. Khalkhoghaev,
  • V.I. Murtazin,
  • A.G. Filippenko
V.V. Shabanov
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk
Bio
V.V. Beloborodov
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk
T.U. Khalkhoghaev
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk
V.I. Murtazin
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk
A.G. Filippenko
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk
An example from the programmer during electrophysiological study after 7 days of constant stimulation
DOI: https://doi.org/10.21688/1681-3472-2023-4-25-32

Published 2023-12-26

Keywords

  • Atrial Fibrillation,
  • Autonomic Nervous System,
  • Denervation,
  • Ganglia, Spinal,
  • Nerve Fibers,
  • Spinal Cord Stimulation,
  • Vagus Nerve Stimulation
    • ...More
    Less

How to Cite

Shabanov, V., Beloborodov, V., Khalkhoghaev, T., Murtazin, V., & Filippenko, A. (2023). Modulation of the autonomic nervous system for preventing perioperative atrial fibrillation: a review of literature. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 27(4), 25–32. https://doi.org/10.21688/1681-3472-2023-4-25-32

Copyright (c) 2023 Shabanov V.V., Beloborodov V.V., Khalkhoghaev T.U., Murtazin V.I., Filippenko A.G.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Introduction: Autonomic control of the heart is exerted by the neurocardiac axis, which comprises reflexes at three levels of cardiac activity: central (higher structures of the forebrain, brainstem, and spinal cord), intrathoracic extracardiac (stellate and dorsal root ganglia), and intracardiac. Neuromodulation of the autonomic nervous system (ANS) (ganglion plexus ablation, epicardial drug infusion for temporary neurotoxicity, low-level vagus nerve stimulation, stellate ganglion blockade, baroreceptor stimulation, spinal cord stimulation, renal and pulmonary artery nerve fiber denervation) is a new therapeutic approach for managing heart rhythm disorders and cardiovascular pathologies. Atrial fibrillation (AF) occurs in up to 30% of patients after open cardiac surgery and is associated with increased morbidity and mortality in the long-term follow-up.
Objective: To evaluate the safety and efficacy of the different neuromodulation approaches for preventing postoperative atrial fibrillation (POAF) in clinical and experimental settings.
Conclusion: ANS neuromodulation techniques have demonstrated high efficacy and safety for preventing POAF.

Received 21 August 2023. Revised 16 October 2023. Accepted 31 October 2023.

Funding: The study was supported by Russian Science Foundation (project No. 22-25-00672).

Conflict of interest: The authors declare no conflict of interest.

Contribution of the authors
Conception and study design: V.V. Shabanov, A.G. Filippenko, V.V. Beloborodov
Drafting the article: V.V. Shabanov, A.G. Filippenko, T.U. Khalkhoghaev, V.I. Murtazin
Critical revision of the article: V.V. Shabanov
Final approval of the version to be published: V.V. Shabanov, V.V. Beloborodov, T.U. Khalkhoghaev, V.I. Murtazin, A.G. Filippenko

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