Vol. 26 No. 4 (2022)
EXPERIMENTAL STUDIES

Diepoxy-treated bovine jugular vein conduit for pulmonary artery replacement

pdf (Русский)
  • N.R. Nichay,
  • I.Yu. Zhuravleva,
  • Yu.Yu. Kulyabin,
  • I.S. Zykov,
  • E.V. Boyarkin,
  • O.Yu. Malakhova,
  • E.V. Kuznetsova,
  • T.P. Timchenko,
  • Ya.L. Rusakova,
  • I.S. Murashov,
  • A.A. Dokuchaeva,
  • A.V. Bogachev-Prokophiev
N.R. Nichay
Meshalkin National Medical Research Center; Novosibirsk State Medical University
Bio
I.Yu. Zhuravleva
Meshalkin National Medical Research Center
Yu.Yu. Kulyabin
Meshalkin National Medical Research Center
I.S. Zykov
Meshalkin National Medical Research Center
E.V. Boyarkin
Meshalkin National Medical Research Center
O.Yu. Malakhova
Meshalkin National Medical Research Center
E.V. Kuznetsova
Meshalkin National Medical Research Center
T.P. Timchenko
Meshalkin National Medical Research Center
Ya.L. Rusakova
Meshalkin National Medical Research Center
I.S. Murashov
Meshalkin National Medical Research Center
A.A. Dokuchaeva
Meshalkin National Medical Research Center
A.V. Bogachev-Prokophiev
Meshalkin National Medical Research Center
Макроскопический вид эксплантированных кондуитов
DOI: https://doi.org/10.21688/1681-3472-2022-4-19-32

Published 2022-12-29

Keywords

  • Animals,
  • Follow-Up Studies,
  • Heart Valve Diseases,
  • Jugular Veins,
  • Right Ventricular Outflow Tract Reconstruction

How to Cite

Nichay, N., Zhuravleva, I., Kulyabin, Y., Zykov, I., Boyarkin, E., Malakhova, O., Kuznetsova, E., Timchenko, T., Rusakova, Y., Murashov, I., Dokuchaeva, A., & Bogachev-Prokophiev, A. (2022). Diepoxy-treated bovine jugular vein conduit for pulmonary artery replacement. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 26(4), 19–32. https://doi.org/10.21688/1681-3472-2022-4-19-32

Copyright (c) 2022 Nichay N.R., Zhuravleva I.Yu., Kulyabin Yu.Yu., Zykov I.S., Boyarkin E.V., Malakhova O.Yu., Kuznetsova E.V., Timchenko T.P., Rusakova Yu.L., Murashov I.S., Dokuchaeva A.A., Bogachev-Prokophiev A.V.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: To evaluate the performance and short-term capacity of the diepoxy-treated bovine jugular vein conduit in large animals during 6-month follow-up.
Methods: Thirteen diepoxy-treated bovine jugular vein conduits were implanted into the pulmonary artery of young mini-pigs. During the follow-up, graft function was tested using transesophageal echocardiography. The animals were withdrawn at 6 months, and the explanted conduits were assessed histologically.
Results: All the conduits were successfully implanted without any surgical complications. All the animals survived throughout the follow-up. By the end of the follow-up period, the pressure gradient increased on five animals’ conduits including one case of mismatch between the conduit and the native pulmonary artery, two cases of distal stenosis, and two case of endocarditis. No significant increase in valve regurgitation or conduit thrombosis was observed during the follow-up. In conduits without dysfunction, the structure of the walls and leaflets was intact. A thin fibrous tissue covered the conduit inner wall with complete surface endothelialization. Neither signs of degeneration or calcification nor inflammatory cells were found in the conduit wall or leaflets. Neointima proliferation without calcium deposits was observed in two distally stenosed conduits. Inflammatory cells consisting of multinucleated macrophages, lymphocytes, and histiocytes were found in the adventitia. There were no inflammatory cells in the media or intima, and the leaflets showed no changes.
Conclusion: Diepoxy-treated bovine jugular vein demonstrated acceptable performance, good endothelialization, and low tendency to thrombosis and calcium accumulation in the wall and leaflets.

Received 31 October 2022. Revised 25 November 2022. Accepted 28 November 2022.

Funding: The study was supported by Russian Science Foundation (grant No. 22-25-20102).

Conflict of interest: The authors declare no conflict of interest.

Contribution of the authors
Conception and study design: N.R. Nichay, I.Yu. Zhuravleva, A.V. Bogachev-Prokophiev
Data collection and analysis: N.R. Nichay, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, E.V. Kuznetsova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. Dokuchaeva
Statistical analysis: N.R. Nichay, I.Yu. Zhuravleva
Drafting the article: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. Dokuchaeva
Critical revision of the article: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, A.A. Dokuchaeva, A.V. Bogachev-Prokophiev
Final approval of the version to be published: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, E.V. Kuznetsova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. Dokuchaeva, A.V. Bogachev-Prokophiev

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