Vol. 26 No. 3 (2022)
EXPERIMENTAL STUDIES

Technical features of a self-expandable prosthetic valve for the treatment of pulmonary valve disease

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  • K.A. Rzaeva,
  • T.P. Timchenko,
  • I.Yu. Zhuravleva,
  • A.N. Arkhipov,
  • A.V. Gorbatykh,
  • A.V. Voitov,
  • N.R. Nichay,
  • A.V. Bogachev-Prokophiev,
  • I.A. Soynov
K.A. Rzaeva
Meshalkin National Medical Research Center
Bio
T.P. Timchenko
Meshalkin National Medical Research Center
I.Yu. Zhuravleva
Meshalkin National Medical Research Center
A.N. Arkhipov
Meshalkin National Medical Research Center
A.V. Gorbatykh
Almazov National Medical Research Centre
A.V. Voitov
Meshalkin National Medical Research Center
N.R. Nichay
Meshalkin National Medical Research Center
A.V. Bogachev-Prokophiev
Meshalkin National Medical Research Center
I.A. Soynov
Meshalkin National Medical Research Center
DOI: https://doi.org/10.21688/1681-3472-2022-3-85-90

Published 2022-09-30

Keywords

  • Biocompatible Materials,
  • Bioprosthesis,
  • Heart Ventricles,
  • Nitinol,
  • Pulmonary Valve

How to Cite

Rzaeva, K., Timchenko, T., Zhuravleva, I., Arkhipov, A., Gorbatykh, A., Voitov, A., Nichay, N., Bogachev-Prokophiev, A., & Soynov, I. (2022). Technical features of a self-expandable prosthetic valve for the treatment of pulmonary valve disease. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 26(3), 85–90. https://doi.org/10.21688/1681-3472-2022-3-85-90

Copyright (c) 2022 Rzaeva K.A., Timchenko T.P., Zhuravleva I.Yu., Arkhipov A.N., Gorbatykh A.V., Voitov A.V., Nichay N.R., Bogachev-Prokophiev A.V., Soynov I.A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background. Balloon-expandable prostheses authorized for transcatheter pulmonary valve replacement in the Russian Federation have a barrel-shaped frame, which requires pre-stenting of a native right ventricular outflow tract or a conduit. This increases procedure duration, complicates implantation technique, and increases operation costs.
Aim. To develop a self-expandable pulmonary valve model for transcatheter replacement and prepare it for preclinical trials.
Methods. The model of a self-expandable pulmonary valve bioprothesis for transcatheter replacement made of nitinol was developed. The leaflets and the lining of the frame were made of porcine pericardium and assembled manually. Radial force testing was performed; valve loading into the delivery system was also tested.
Results. According to the results of the tests, the valve biomaterial and the suture sites were not damaged after compression. In 2022, initial preclinical tests are scheduled to determine viability of the implanted valves at 6 and 12 months after surgery, and the rate of calcification for this observation period is to be assessed as well.
Conclusion. By optimizing the design of the support frame, we improved the transcatheter model of the biological valve with satisfactory results at the initial stage of preclinical trials.

Received 22 April 2022. Revised 5 May 2022. Accepted 11 May 2022.

Funding: This work is supported by a grant of the Russian Science Foundation (project No. 21-75-10041).

Conflict of interest: Authors declare no conflict of interest.

Contribution of the authors
Conception and study design: K.A. Rzaeva, T.P. Timchenko, A.N. Arkhipov, N.R. Nichay
Data collection and analysis: A.V. Voitov, N.R. Nichay
Drafting the article: K.A. Rzaeva, A.V. Gorbatykh
Critical revision of the article: I.Yu. Zhuravleva, I.A. Soynov, A.V. Bogachev-Prokophiev
Final approval of the version to be published: K.A. Rzaeva, T.P. Timchenko, I.Yu. Zhuravleva, A.N. Arkhipov, A.V. Gorbatykh, A.V. Voitov, N.R. Nichay, A.V. Bogachev-Prokophiev, I.A. Soynov

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