Vol. 17 No. 3 (2013)
CORONARY ARTERY DISEASES

N-terminal natriuretic propeptide in diagnostics of myocardial injuries after coronary artery bypass grafting on a beating heart

O. Petrova
Federal Center of Cardiovascular Surgery, Astrakhan
Bio
A. Motreva
Federal Center of Cardiovascular Surgery, Astrakhan
Bio
Yu. Martyanova
Federal Center of Cardiovascular Surgery, Astrakhan
Bio
A. Kadykova
Federal Center of Cardiovascular Surgery, Astrakhan
Bio
S. Shashin
Federal Center of Cardiovascular Surgery, Astrakhan
Bio
D. Tarasov
Federal Center of Cardiovascular Surgery, Astrakhan
Bio

Published 2013-09-17

Keywords

  • ISCHEMIC HEART DISEASE,
  • CABG,
  • MYOCARDIAL INJURY MARKERS,
  • TROPONIN Т,
  • N-TERMINAL NATRIURETIC PROPEPTIDE

How to Cite

Petrova, O., Motreva, A., Martyanova, Y., Kadykova, A., Shashin, S., & Tarasov, D. (2013). N-terminal natriuretic propeptide in diagnostics of myocardial injuries after coronary artery bypass grafting on a beating heart. Patologiya Krovoobrashcheniya I Kardiokhirurgiya, 17(3), 18–21. https://doi.org/10.21688/1681-3472-2013-3-18-21

Abstract

Dynamics of N-terminal natriuretic propeptide (NT-proBNP) and troponin T in the blood of patients with ischemic heart disease after CABG on a beating heart is studied. It is found out that the level of NT-proBNP in patients with ischemic heart disease at admission correlates with their functional class, left ventricular ejection fraction and end-diastolic volume). It is also shown that the level of NT-proBNP increases in 1 day after CABG and reaches the maximum values in3 days. At the 15th day a decrease in the level of NT-proBNP is observed, however, which reaches the baseline values. The analysis of correlation between NT-proBNP and troponin Т has revealed an inverse correlation between the indicators under study, which testifies to the fact that NT-proBNP cannot be used as a myocardial injury marker in patients with ischemic heart disease after CABG.

References

  1. Андреев Д.А. // Лабораторная медицина. 2003. № 6. С. 42-46.
  2. Барбараш О.Л., Усольцева Е.Н. // Патология кровообращения и кардиохирургия. 2004. № 4. С. 74-78.
  3. Бокерия, Л.А., Самуилова Д.Ш., Плющ М.Г. // Грудная и сердечно-сосудистая хирургия. 2007. № 4. С.61-65.
  4. Гланц С. Медико-биологическая статистика. М., 1998.
  5. Морозов Ю.А., Гончарова А.А., Чарная М.А. // Грудная и сердечно-сосудистая хирургия. 2009. № 3. С. 54-56.
  6. Мошкин И.К., Шумаков Д.В. // Лаборатория. 2005. № 2. С. 6-7.
  7. Козлов, И.А., Харламова И.Е., Кричевский Л.А. // Общая реаниматология. 2009. № 3. С. 24-28.
  8. Сапрыгин Д.Б., Мошина В.А. // Лабораторная медицина. 2003. № 8. С. 1-8.
  9. Шумаков Д.В., Шевченко О.П., Орлова О.В. и др. // Вест. трансплантологии и искусственных органов. 2007. № 1. С. 54-61.
  10. Hutfless R., Kazanegra R., Madani M. et al. // J. Ann. Coll. Cardiol. 2004. V. 43. P. 1873-1879.
  11. Lee T.H., Thomas E.J., Ludwig L.E. // Am. J. Cardiol. 1996. V. 77. P. 1031-1036.
  12. Morimoto K., Mori T., Ishiguro S et al. // Surg. Today. 1998. V. 28. P. 23-29.
  13. Richards M., Nicholls M.G., Espiner E.A. et al. // J. Am. Coll. Cardiol. 2006. V. 47. P. 52-60.
  14. Vanderheyden M. Bartenek J., Goethals M. // Eur. J. Heart Fail. 2004. V. 110. P. 124-127.